Molecular Diagnosis Center, The Affiliated Hospital of Chengde Medical University, Chengde, HeBei Province, 067000, China.
BMC Psychiatry. 2023 Aug 2;23(1):559. doi: 10.1186/s12888-023-05035-w.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting ~ 2% of children worldwide and is characterized by repetitive, stereotypical behaviours and impaired expressive communication. Cytomegalovirus (CMV) is considered a risk factor for ASD; however, published studies are usually limited by covering too few events and have different conclusions, indicating that the relationship between CMV infection and ASD remains elusive.
To investigate the association between CMV infection and ASD, we conducted this 2-sample Mendelian randomization (MR) study using genome-wide association studies (GWAS) summary data from FinnGen and the IEU Open GWAS project.
Our results showed no significant relationship between all 3 CMV infections (unspecified cytomegaloviral diseases, anti-CMV IgG levels, and maternal CMV) and ASD.
Our results indicate that CMV infection does not significantly increase ASD risk. These results show that the relationship between CMV infection and ASD remains elusive and needs to be further clarified.
自闭症谱系障碍（ASD）是一种影响全球约 2%儿童的神经发育障碍，其特征是重复、刻板的行为和表达性沟通障碍。巨细胞病毒（CMV）被认为是 ASD 的一个危险因素；然而，已发表的研究通常受到覆盖事件太少的限制，且得出的结论也不同，这表明 CMV 感染与 ASD 之间的关系仍不清楚。
为了研究 CMV 感染与 ASD 之间的关联，我们使用 FinnGen 和 IEU Open GWAS 项目的全基因组关联研究（GWAS）汇总数据进行了这项双样本 Mendelian 随机化（MR）研究。
我们的结果表明，所有 3 种 CMV 感染（未特指的巨细胞病毒病、抗 CMV IgG 水平和母体 CMV）与 ASD 之间均无显著关系。
我们的结果表明，CMV 感染不会显著增加 ASD 的风险。这些结果表明，CMV 感染与 ASD 之间的关系仍不清楚，需要进一步阐明。
