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经食管支架置入胆总管治疗不可切除性胆管内乳头状黏液性肿瘤:病例报告

Unconventional treatment of inoperable biliary IPMN with an oesophageal stent in the common bile duct: case report.

作者信息

Siiki Antti, Antila Anne, Vaalavuo Yrjö, Ronkainen Johanna, Rinta-Kiikka Irina, Laukkarinen Johanna

机构信息

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, PO BOX 2000, 33521 Tampere, Finland.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.

出版信息

Ther Adv Gastrointest Endosc. 2023 Jul 31;16:26317745231183311. doi: 10.1177/26317745231183311. eCollection 2023 Jan-Dec.

Abstract

Biliary intraductal papillary mucinous neoplasm (IPMN) is a rare biliary neoplasia preferably treated with oncologic resection. Endoscopic radio frequency (RF) ablation may be used as a palliative measure. We present a rare case, where heavy co-morbidities prevented surgery. Continuous mucus production caused recurrent episodes of severe cholangitis. Several ERCPs (endoscopic retrograde cholangio pancretography) were necessary due to recurrent biliary obstruction. RF ablation was not effective in the dilated common bile duct without a stricture. Standard biliary stents failed due to either migration or occlusion. When other options failed, an exceptional decision was made: a covered large diameter oesophageal stent was inserted in ERCP into the bile duct to secure bile flow and stop mucus production. Digital cholangioscopy was crucial adjunct to standard ERCP in endoscopic management. The palliative treatment method was successful: there were no stent-related adverse events or readmissions for cholangitis. The follow-up in the palliative care lasted until patient's last 10 months of lifetime.

摘要

胆管内乳头状黏液性肿瘤(IPMN)是一种罕见的胆管肿瘤,最好采用肿瘤切除治疗。内镜射频(RF)消融可作为一种姑息性措施。我们报告一例罕见病例,患者因严重的合并症而无法进行手术。持续的黏液分泌导致严重胆管炎反复发作。由于反复出现胆管梗阻,需要多次进行内镜逆行胰胆管造影(ERCP)。射频消融对无狭窄的扩张胆总管无效。标准胆管支架因移位或堵塞而失败。当其他选择均告失败时,做出了一个特殊决定:在ERCP操作中将一个带覆膜的大口径食管支架插入胆管,以确保胆汁流动并阻止黏液分泌。数字胆管镜检查是内镜治疗中标准ERCP的关键辅助手段。姑息治疗方法取得成功:未发生与支架相关的不良事件,也没有因胆管炎再次入院。姑息治疗的随访持续到患者生命的最后10个月。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a5/10392209/ec352a46a910/10.1177_26317745231183311-fig1.jpg

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