Akiyama Sae, Murayama Chisa, Aizawa Saori, Mizushima Arei, Maeda Yukiko, Taniguchi Natsuko, Nagai Katsura, Harada Toshiyuki
Center for Respiratory Diseases Japan Community Healthcare Organization Hokkaido Hospital Sapporo Japan.
Respirol Case Rep. 2023 Jul 31;11(9):e01201. doi: 10.1002/rcr2.1201. eCollection 2023 Sep.
A 35-year-old woman experienced left back pain after a 2-h flight. She reported coughing and left back pain 1 day later when she presented to our hospital. Chest computed tomography showed pneumothorax of the left lung, bronchiectasis, thickening of the bronchial wall, nodules, and cavity lesions in both lungs. A pulmonary function test revealed obstructive ventilation disorder with normal lung diffusing capacity. She had a history of haematopoietic stem cell transplantation (HSCT) at 2 years and 3 months of age during the second disease remission of acute myeloid leukaemia. She was diagnosed with chronic graft-versus-host disease (cGVHD) presenting with bronchiolitis obliterans (BO) and pleuroparenchymal fibroelastosis (PPFE). To our knowledge, this is the first reported case of BO and PPFE diagnosed more than 30 years after HSCT.
一名35岁女性在乘坐2小时航班后出现左背部疼痛。1天后她前来我院就诊，自述咳嗽及左背部疼痛。胸部计算机断层扫描显示左肺气胸、支气管扩张、支气管壁增厚、双肺结节及空洞病变。肺功能测试显示为阻塞性通气障碍，肺弥散功能正常。她在急性髓系白血病第二次疾病缓解期，于2岁3个月时接受过造血干细胞移植（HSCT）。她被诊断为慢性移植物抗宿主病（cGVHD），表现为闭塞性细支气管炎（BO）和胸膜实质纤维弹性组织增生症（PPFE）。据我们所知，这是首例报道的HSCT后30多年诊断出BO和PPFE的病例。
