Dong Jiawei, Wang Fang, Xu Yuyun, Gao Xin, Zhao Hongtao, Zhang Jiheng, Wang Nan, Liu Zhihui, Yan Xiuwei, Jin Jiaqi, Ji Hang, Cheng Ruiqi, Wang Lihai, Qiu Zhaowen, Hu Shaoshan
Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Cancer Center, Department of Neurosurgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Front Med (Lausanne). 2023 Jul 18;10:1171819. doi: 10.3389/fmed.2023.1171819. eCollection 2023.
Photodynamic therapy (PDT) promotes significant tumor regression and extends the lifetime of patients. The actual operation of PDT often relies on the subjective judgment of experienced neurosurgeons. Patients can benefit more from precisely targeting PDT's key operating zones.
We used magnetic resonance imaging scans and created 3D digital models of patient anatomy. Multiple images are aligned and merged in STL format. Neurosurgeons use HoloLens to import reconstructions and assist in PDT execution. Also, immunohistochemistry was used to explore the association of hyperperfusion sites in PDT of glioma with patient survival.
We constructed satisfactory 3D visualization of glioma models and accurately localized the hyperperfused areas of the tumor. Tumor tissue taken in these areas was rich in CD31, VEGFA and EGFR that were associated with poor prognosis in glioma patients. We report the first study using MR technology combined with PDT in the treatment of glioma. Based on this model, neurosurgeons can focus PDT on the hyperperfused area of the glioma. A direct benefit was expected for the patients in this treatment.
Using the Mixed Reality technique combines multimodal imaging signatures to adjuvant glioma PDT can better exploit the vascular sealing effect of PDT on glioma.
光动力疗法（PDT）可促使肿瘤显著消退并延长患者生存期。PDT的实际操作通常依赖经验丰富的神经外科医生的主观判断。精准靶向PDT的关键操作区域能让患者获益更多。
我们使用磁共振成像扫描并创建患者解剖结构的3D数字模型。多幅图像以STL格式对齐并合并。神经外科医生使用HoloLens导入重建模型并协助执行PDT。此外，采用免疫组织化学方法探讨胶质瘤PDT中高灌注部位与患者生存的相关性。
我们构建了令人满意的胶质瘤模型3D可视化图像，并准确地定位了肿瘤的高灌注区域。取自这些区域的肿瘤组织富含CD31、VEGFA和EGFR，这些与胶质瘤患者的不良预后相关。我们报道了首例使用磁共振技术联合PDT治疗胶质瘤的研究。基于此模型，神经外科医生可将PDT聚焦于胶质瘤的高灌注区域。预计该治疗对患者有直接益处。
使用混合现实技术结合多模态成像特征辅助胶质瘤PDT，能够更好地利用PDT对胶质瘤的血管封闭效应。
