多聚阴离子诱导单峰驼血红蛋白的构象变化。对三价铁衍生物的研究。
Conformational changes induced by polyanions in haemoglobin from Camelus dromedarius. Studies on the ferric derivatives.
作者信息
Santucci R, Ascoli F, Amiconi G, Brunori M
出版信息
Biochem J. 1986 May 1;235(3):791-5. doi: 10.1042/bj2350791.
Abstract
The effect of inositol hexakisphosphate on the redox equilibria and on the c.d. spectra of ferric derivatives of haemoglobin from Camelus dromedarius has shown that: two distinct functionally relevant binding sites for polyanions are present on the protein; conformational changes promoted by inositol hexakisphosphate are largely dependent on spin state of the iron; tertiary and quaternary changes are not necessarily linked; structures induced by polyanions can be mixed forms that are neither T-state nor R-state.
摘要
肌醇六磷酸对单峰驼血红蛋白铁衍生物的氧化还原平衡及圆二色光谱的影响表明
该蛋白质上存在两个与功能相关的不同多阴离子结合位点；肌醇六磷酸促进的构象变化在很大程度上取决于铁的自旋状态；三级和四级变化不一定相关联；多阴离子诱导的结构可以是既非T态也非R态的混合形式。
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引用本文的文献
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