Varga J, Jimenez S A
Arthritis Rheum. 1986 Sep;29(9):1160-5. doi: 10.1002/art.1780290916.
We describe 2 patients with Raynaud's phenomenon who developed severe sclerodermatous changes after immobilization. The scleroderma was confined to the immobilized limb. Histologic examination of tissue samples of the affected skin showed mononuclear cell infiltrates and marked collagen deposition in the dermis and subcutaneous adipose tissue. In vitro biosynthetic studies demonstrated a dramatic increase in collagen production by cultures of involved skin from one of the patients. These results suggest that immobilization resulted in activation of dermal fibroblasts (perhaps mediated by inflammatory cells) and in the subsequent development of fibrosis in both of these patients.
我们描述了2例患有雷诺现象的患者，他们在肢体固定后出现了严重的硬皮病样改变。硬皮病局限于固定的肢体。对受累皮肤组织样本的组织学检查显示，真皮和皮下脂肪组织有单核细胞浸润和明显的胶原沉积。体外生物合成研究表明，其中1例患者受累皮肤培养物的胶原生成显著增加。这些结果提示，肢体固定导致了真皮成纤维细胞的激活（可能由炎症细胞介导），并在这2例患者中随后出现了纤维化。
