RSU 1069，一种含有氮丙啶基团的硝基咪唑。生物还原在缺氧条件下会大大增加细胞毒性。 - Suppr

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超能文献

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.

作者信息

Stratford I J, O'Neill P, Sheldon P W, Silver A R, Walling J M, Adams G E

出版信息

Biochem Pharmacol. 1986 Jan 1;35(1):105-9. doi: 10.1016/0006-2952(86)90566-6.

DOI:10.1016/0006-2952(86)90566-6

PMID:3753579

Abstract

摘要

相似文献

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.RSU 1069，一种含有氮丙啶基团的硝基咪唑。生物还原在缺氧条件下会大大增加细胞毒性。

Biochem Pharmacol. 1986 Jan 1;35(1):105-9. doi: 10.1016/0006-2952(86)90566-6.

The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action.RSU 1069的差异细胞毒性：细胞存活研究表明与DNA相互作用可能是其作用方式。

Br J Cancer. 1986 Mar;53(3):339-44. doi: 10.1038/bjc.1986.57.

Analogues of RSU-1069: radiosensitization and toxicity in vitro and in vivo.

Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1079-81. doi: 10.1016/0360-3016(86)90230-0.

Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.

Biochem Pharmacol. 1988 Oct 15;37(20):3837-42. doi: 10.1016/0006-2952(88)90064-0.

Metabolism and radiosensitization of 4,5-dimethylmisonidazole, a ring-substituted analog of misonidazole.米索硝唑的环取代类似物4,5-二甲基米索硝唑的代谢与放射增敏作用

Biochem Pharmacol. 1992 Mar 17;43(6):1337-44. doi: 10.1016/0006-2952(92)90511-g.

Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues.关于RSU-1069及其类似物的放射增敏和细胞毒性特性机制的研究。

Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1083-6. doi: 10.1016/0360-3016(86)90231-2.

Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.

Biochem Pharmacol. 1992 Oct 6;44(7):1341-7. doi: 10.1016/0006-2952(92)90535-q.

Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro.硝基咪唑-氮丙啶放射增敏剂RSU-1069诱导DNA链断裂。未还原形式和辐射还原形式与DNA结合的作用，体外研究。

Biochem Pharmacol. 1985 Oct 1;34(19):3537-42. doi: 10.1016/0006-2952(85)90730-0.

Comparative DNA damage induced by nitroimidazole-aziridine drugs: 1. Effects of methyl substitution on drug action.

Anticancer Drug Des. 1988 Dec;3(3):169-75.

Studies on the toxicity of RSU-1069.RSU-1069的毒性研究。

Int J Radiat Oncol Biol Phys. 1986 Jul;12(7):1219-22. doi: 10.1016/0360-3016(86)90262-2.

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Hypoxia-targeted drug delivery.缺氧靶向药物递送。

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Modulation of the tumor vasculature and oxygenation to improve therapy.调节肿瘤血管系统和氧合作用以改善治疗效果。

Pharmacol Ther. 2015 Sep;153:107-24. doi: 10.1016/j.pharmthera.2015.06.006. Epub 2015 Jun 11.

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours.平台期培养物：一种用于鉴定在实体瘤微环境中被生物活化的药物的实验模型。

Br J Cancer. 1997;75(2):196-201. doi: 10.1038/bjc.1997.33.

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro.使用彗星试验测量的替拉扎明诱导的DNA损伤与体外对缺氧肿瘤细胞的细胞毒性相关。

Br J Cancer. 1996 Apr;73(8):952-60. doi: 10.1038/bjc.1996.187.

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.SR 4233（替拉扎明）：一种利用实体瘤缺氧特性的新型抗癌药物。

Br J Cancer. 1993 Jun;67(6):1163-70. doi: 10.1038/bjc.1993.220.

Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069.通过测量暴露于生物还原药物的球体和小鼠肿瘤中单个细胞的DNA损伤来检测缺氧。II. RSU 1069。

Br J Cancer. 1995 Mar;71(3):537-42. doi: 10.1038/bjc.1995.106.

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).细胞色素P450还原酶活性在决定乳腺肿瘤细胞对生物还原药物替拉扎明（SR 4233）敏感性中的重要性。

Br J Cancer. 1995 Nov;72(5):1144-50. doi: 10.1038/bjc.1995.478.

Potentiation of RSU-1069 tumour cytotoxicity by 5-hydroxytryptamine (5-HT).5-羟色胺（5-HT）增强RSU-1069的肿瘤细胞毒性作用

Br J Cancer. 1986 Nov;54(5):727-31. doi: 10.1038/bjc.1986.233.

Pharmacokinetics and metabolism of the mixed-function hypoxic cell sensitizer prototype RSU 1069 in mice.多功能低氧细胞增敏剂原型RSU 1069在小鼠体内的药代动力学与代谢

Cancer Chemother Pharmacol. 1988;22(4):275-81. doi: 10.1007/BF00254231.

High uptake of RSU 1069 and its analogues melanotic melanomas.RSU 1069及其类似物在黑色素瘤中摄取率高。

Cancer Chemother Pharmacol. 1989;24(1):28-32. doi: 10.1007/BF00254101.

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