肌钙蛋白I、N末端B型利钠肽原及联合检测在急性心肌梗死患者中的诊断价值

Diagnostic Value of cTnl, NT-pro BNP, and Combined Tests in Acute Myocardial Infarction Patients.

作者信息

Shi Junhui, Wang Wei, Sun Yongfang, Zhou Minzhi, Liu Jiang

出版信息

Altern Ther Health Med. 2023 Oct;29(7):412-417.

Abstract

OBJECTIVE

Acute myocardial infarction (AMI) is characterized by heart damage resulting from blocked blood flow. Prompt diagnosis is vital for timely treatment and saving lives. This study aimed to evaluate the diagnostic value of cTnl, NT-pro BNP, and a combined test in AMI patients.

METHODS

In this study, a retrospective observational design was employed, and we selected 221 patients with AMI admitted to our hospital within a 3-year period as the research subjects and included them in the AMI group. Additionally, 200 patients from the control group, who visited our hospital for physical examinations, were selected to compare the expressions of cardiac Troponin I (cTnl) and N-Terminal pro-B-type Natriuretic Peptide (NT-pro BNP) between the two groups. Receiver Operating Characteristic (ROC) curves were constructed to analyze the diagnostic value of cTnl combined with NT-pro BNP for AMI. Furthermore, AMI patients were categorized into four groups based on the New York Heart Association (NYHA) classification (grades I, II, III, and IV). The differences in cTnl, NT-pro BNP, and Left Ventricular Ejection Fraction (LVEF) were compared among the AMI patients with different cardiac function grades to analyze their correlation and diagnostic value in assessing the severity of AMI-related cardiac insufficiency.

RESULTS

The levels of cTnl and NT-pro BNP in AMI patients were significantly higher than those in the control group, and their combined detection effectively facilitated the diagnosis of AMI occurrence. Moreover, cTnl and NT-pro BNP concentrations increased with the severity of cardiac dysfunction (NYHA grades) and showed a notable negative correlation with LVEF. Furthermore, the combined testing of cTnl and NT-pro BNP demonstrated significant value in evaluating the severity of AMI in patients.

CONCLUSIONS

The combined detection of cTnl and NT-pro BNP holds considerable application value in diagnosing AMI occurrence and assessing its severity.

摘要

目的

急性心肌梗死（AMI）的特征是因血流受阻导致心脏损伤。及时诊断对于及时治疗和挽救生命至关重要。本研究旨在评估cTnl、NT-pro BNP及联合检测在AMI患者中的诊断价值。

方法

本研究采用回顾性观察设计，选取3年内我院收治的221例AMI患者作为研究对象，纳入AMI组。此外，选取200例来我院进行体检的对照组患者，比较两组心肌肌钙蛋白I（cTnl）和N末端B型利钠肽原（NT-pro BNP）的表达。构建受试者工作特征（ROC）曲线，分析cTnl联合NT-pro BNP对AMI的诊断价值。此外，根据纽约心脏协会（NYHA）分级（I、II、III和IV级）将AMI患者分为四组。比较不同心功能分级的AMI患者cTnl、NT-pro BNP和左心室射血分数（LVEF）的差异，分析它们在评估AMI相关心功能不全严重程度方面的相关性和诊断价值。