Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, 80336 Munich, Germany.
Department of Endocrinology, Aix Marseille University, MMG, INSERM U1251, MarMaRa Institute, CRMR HYPO, Marseille 13385, France.
Eur J Endocrinol. 2023 Aug 2;189(2):R1-R10. doi: 10.1093/ejendo/lvad097.
Acromegaly is a rare and insidious disease characterized by chronic excess growth hormone, leading to various morphological changes and systemic complications. Despite its low prevalence, acromegaly poses a significant socioeconomic burden on patients and healthcare systems. This review synthesizes the current state of knowledge on the psychosocial burden, disability, impact on daily life, and cost of acromegaly disease, focusing on the quality of life, partnership, medical care and treatment afflictions, participation in daily activities, professional and leisure impairment, and cost of treatment for acromegaly and its comorbidities. It also examines management strategies, coping mechanisms, and interventions aimed at alleviating this burden. A comprehensive understanding of the extent of the socioeconomic burden in acromegaly is crucial to develop effective strategies to improve treatment and care. Further research is warranted to explore the myriad factors contributing to this burden, as well as the efficacy of interventions to alleviate it, ultimately enhancing the quality of life for patients with acromegaly.
肢端肥大症是一种罕见且隐匿的疾病，其特征为慢性生长激素过多，导致各种形态学改变和全身并发症。尽管肢端肥大症的发病率较低，但它给患者和医疗保健系统带来了重大的社会经济负担。本综述综合了肢端肥大症的社会心理负担、残疾、对日常生活的影响和疾病治疗费用的现有知识，重点关注生活质量、伴侣关系、医疗和治疗困扰、日常活动参与、职业和休闲障碍以及肢端肥大症及其合并症的治疗费用。还探讨了管理策略、应对机制和旨在减轻这种负担的干预措施。全面了解肢端肥大症的社会经济负担程度对于制定有效的治疗和护理策略至关重要。需要进一步研究来探讨导致这种负担的众多因素，以及减轻这种负担的干预措施的效果，最终提高肢端肥大症患者的生活质量。
