时机很重要：星形胶质细胞反应在神经退行性变中的保护作用。
Timing matters: A protective role of astrocyte reactivity in neurodegeneration.
机构信息
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
出版信息
Neuron. 2023 Aug 2;111(15):2277-2279. doi: 10.1016/j.neuron.2023.06.014.
Abstract
Sheehan and Nadarajah et al. identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer's disease patients and in disease-associated astrocytes, enhancing the phagocytosis of misfolded proteins and preventing tau and alpha-synuclein pathologies.
摘要
希恩和纳达拉加等人发现，星形胶质细胞中 Bmal1 的缺失会诱导 BAG3 的表达，BAG3 是一种在阿尔茨海默病患者和疾病相关星形胶质细胞中丰富的巨自噬伴侣，增强了错误折叠蛋白的吞噬作用，并防止 tau 和 alpha-synuclein 病理。
相似文献
1
Timing matters: A protective role of astrocyte reactivity in neurodegeneration.时机很重要：星形胶质细胞反应在神经退行性变中的保护作用。
Neuron. 2023 Aug 2;111(15):2277-2279. doi: 10.1016/j.neuron.2023.06.014.
2
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.星形胶质细胞 BMAL1-BAG3 轴可预防 α-突触核蛋白和 tau 病理。
Neuron. 2023 Aug 2;111(15):2383-2398.e7. doi: 10.1016/j.neuron.2023.05.006. Epub 2023 Jun 13.
3
Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease.人类 CA1 海马亚区的神经退行性变和星形胶质细胞增生与阿尔茨海默病中的 hsp90ab1 和 bag3 有关。
Int J Mol Sci. 2021 Dec 23;23(1):165. doi: 10.3390/ijms23010165.
4
[Abeta, tau and alpha-synuclein and glial cells].[β-淀粉样蛋白、tau蛋白、α-突触核蛋白与神经胶质细胞]
Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Feb;26(1):23-31.
5
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.BAG3 和 SYNPO（突触蛋白）通过自噬促进神经元突起中磷酸化 MAPT/Tau 的降解。
Autophagy. 2019 Jul;15(7):1199-1213. doi: 10.1080/15548627.2019.1580096. Epub 2019 Mar 1.
6
BAG3 facilitates the clearance of endogenous tau in primary neurons.BAG3促进原代神经元中内源性tau蛋白的清除。
Neurobiol Aging. 2015 Jan;36(1):241-8. doi: 10.1016/j.neurobiolaging.2014.08.012. Epub 2014 Aug 16.
7
Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases.散发性阿尔茨海默病和帕金森病中异常tau蛋白和α-突触核蛋白传播的潜在途径
Cold Spring Harb Perspect Biol. 2016 Nov 1;8(11):a023630. doi: 10.1101/cshperspect.a023630.
8
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.tau 平衡特征与兴奋性神经元的细胞和区域易感性有关，易感性与 tau 病理学有关。
Nat Neurosci. 2019 Jan;22(1):47-56. doi: 10.1038/s41593-018-0298-7. Epub 2018 Dec 17.
9
A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.BAG3在通过选择性巨自噬调节SNCA/α-突触核蛋白清除中的作用。
Neurobiol Aging. 2017 Dec;60:104-115. doi: 10.1016/j.neurobiolaging.2017.08.023. Epub 2017 Sep 1.
10
Tau Pathology Drives Disease-Associated Astrocyte Reactivity in Salt-Induced Neurodegeneration.tau蛋白病变在盐诱导的神经退行性变中驱动疾病相关的星形胶质细胞反应性。
Adv Sci (Weinh). 2025 Mar;12(11):e2410799. doi: 10.1002/advs.202410799. Epub 2025 Jan 24.
引用本文的文献
1
Editorial: Function and regulation of non-neuronal cells in the nervous system.社论：神经系统中非神经元细胞的功能与调节
Front Cell Neurosci. 2025 Feb 7;19:1550903. doi: 10.3389/fncel.2025.1550903. eCollection 2025.
本文引用的文献
1
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.星形胶质细胞 BMAL1-BAG3 轴可预防 α-突触核蛋白和 tau 病理。
Neuron. 2023 Aug 2;111(15):2383-2398.e7. doi: 10.1016/j.neuron.2023.05.006. Epub 2023 Jun 13.
2
Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway.反应性星形胶质细胞通过JAK2-STAT3信号通路促进亨廷顿舞蹈病中的蛋白质稳态。
Brain. 2023 Jan 5;146(1):149-166. doi: 10.1093/brain/awac068.
3
Astrocytic α2-Na/K ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model.星形胶质细胞 α2-Na/K ATP 酶抑制可抑制星形胶质细胞反应性并减少 tau 病小鼠模型中的神经退行性变。
Sci Transl Med. 2022 Feb 16;14(632):eabm4107. doi: 10.1126/scitranslmed.abm4107.
4
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.生物钟基因 Bmal1 缺失的星形胶质细胞在淀粉样蛋白-β病理学中表现出增强的激活反应，而斑块负担没有改变。
Sci Rep. 2022 Feb 2;12(1):1796. doi: 10.1038/s41598-022-05862-z.
5
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.反应性星形胶质细胞在应对 Tau 和 Aβ 病理时会获得神经保护和有害特征。
Nat Commun. 2022 Jan 10;13(1):135. doi: 10.1038/s41467-021-27702-w.
6
BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance.BAG3 通过调控 RAB35 调节内体分选复合物对于运输/内溶酶体途径和 Tau 清除的作用。
Biol Psychiatry. 2022 Jul 1;92(1):10-24. doi: 10.1016/j.biopsych.2021.10.024. Epub 2021 Nov 10.
7
Biomarkers for neurodegenerative diseases.神经退行性疾病的生物标志物。
Nat Med. 2021 Jun;27(6):954-963. doi: 10.1038/s41591-021-01382-x. Epub 2021 Jun 3.
8
Circadian regulation of astrocyte function: implications for Alzheimer's disease.生物钟对星形胶质细胞功能的调节：对阿尔茨海默病的影响。
Cell Mol Life Sci. 2020 Mar;77(6):1049-1058. doi: 10.1007/s00018-019-03314-y. Epub 2019 Sep 27.
9
Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1.生物钟蛋白 BMAL1 对星形胶质细胞激活的细胞自主调控。
Cell Rep. 2018 Oct 2;25(1):1-9.e5. doi: 10.1016/j.celrep.2018.09.015.
10
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.生物钟蛋白调节神经元氧化还原稳态和神经退行性变。
J Clin Invest. 2013 Dec;123(12):5389-400. doi: 10.1172/JCI70317. Epub 2013 Nov 25.
Zotero 插件