Centre for Drug Research, Universiti Sains Malaysia, 11800, Penang, Malaysia.
Centre for Drug Research, Universiti Sains Malaysia, 11800, Penang, Malaysia.
Regul Toxicol Pharmacol. 2023 Sep;143:105466. doi: 10.1016/j.yrtph.2023.105466. Epub 2023 Aug 1.
Mitragyna speciosa Korth also known as kratom, is an herbal drug preparation for its therapeutic properties and opioid-replacement therapy. Kratom is consumed in a brewed decoction form in Malaysia and to date, no studies have characterized its chemical and toxicity profile. Thus, this study aims to evaluate kratom decoction's safety and toxicity profile after 28 days of treatment. Mitragynine content was quantified in kratom decoction and used as a marker to determine the concentration. Male and female Sprague Dawley rats were orally treated with vehicle or kratom decoction (10, 50 or 150 mg/kg) and two satellite groups were treated with vehicle and kratom decoction (150 mg/kg). Blood and organs were collected for hematology, biochemical and histopathology analysis at the end of treatment. No mortality was found after 28 days of treatment and no significant changes in body weight and hematology profile, except for low platelet count. High amounts of uric acid, AST, ALT and alkaline phosphatase were found in the biochemical analysis. Histological investigation of the heart and lungs detected no alterations except for the kidney, liver and brain tissues. In conclusion, repeated administration of kratom decoction provided some evidence of toxicity in the kidney and liver with no occurrence of mortality.
美托拉宗，又名咔特，是一种草药药物制剂，具有治疗特性和阿片类药物替代治疗作用。咔特以煮成的汤剂形式在马来西亚被消耗，迄今为止，尚无研究对其化学和毒性特征进行描述。因此，本研究旨在评估咔特汤剂在治疗 28 天后的安全性和毒性特征。咔特汤剂中的美托拉宗含量被定量，并用作确定浓度的标志物。雄性和雌性斯普拉格-道利大鼠经口给予载体或咔特汤剂（10、50 或 150mg/kg），并给予两个卫星组载体和咔特汤剂（150mg/kg）。在治疗结束时，收集血液和器官进行血液学、生物化学和组织病理学分析。28 天治疗后无死亡，体重和血液学特征无显著变化，除血小板计数较低外。生化分析发现尿酸、AST、ALT 和碱性磷酸酶含量较高。心脏和肺部的组织学检查除肾脏、肝脏和脑组织外，未发现任何改变。总之，重复给予咔特汤剂在肾脏和肝脏中提供了一些毒性证据，但未发生死亡。
