Gao Xin-Xin, Zuo Qian-Lin, Fu Xi-Hang, Song Ling-Ling, Cen Man-Qiu, Wu Jing
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Environ Res. 2023 Nov 1;236(Pt 2):116812. doi: 10.1016/j.envres.2023.116812. Epub 2023 Aug 1.
Although numerous studies have examined the effect of prenatal per- and polyfluoroalkyl substances (PFAS) exposure on neurodevelopment in children, findings have been inconsistent.
To better understand the effects of PFAS exposure during pregnancy on offspring neurodevelopment, we conducted a systematic review of prenatal exposure to different types of PFAS and neurodevelopment in children.
A comprehensive search was conducted in the PubMed, Web of Science, and EMBASE electronic databases up to March 2023. Only birth cohort studies that report a specific association between PFAS exposure during pregnancy and neurodevelopment were included in this review.
31 birth cohort studies that met the inclusion criteria were qualitatively integrated. Among these, 14 studies investigated the impact of PFAS exposure during pregnancy on cognition, 13 on neurobehavior, and 4 on both cognition and neurobehavior. Additionally, 4 studies explored the influence of PFAS on children's comprehensive development.
Prenatal PFAS exposure was associated with poor neurodevelopment in children, including psychomotor development, externalizing behavior, and comprehensive development. However, conclusive evidence regarding its effects on other neurological outcomes remains limited. In addition, sex-specific effects on social behavior and sleep problems were identified.
尽管众多研究已考察了孕期全氟和多氟烷基物质（PFAS）暴露对儿童神经发育的影响，但研究结果并不一致。
为了更好地了解孕期PFAS暴露对后代神经发育的影响，我们对孕期不同类型PFAS暴露与儿童神经发育进行了系统综述。
截至2023年3月，在PubMed、科学网和EMBASE电子数据库中进行了全面检索。本综述仅纳入报告孕期PFAS暴露与神经发育之间特定关联的出生队列研究。
对31项符合纳入标准的出生队列研究进行了定性整合。其中，14项研究调查了孕期PFAS暴露对认知的影响，13项研究调查了对神经行为的影响，4项研究同时调查了对认知和神经行为的影响。此外，4项研究探讨了PFAS对儿童综合发育的影响。
孕期PFAS暴露与儿童神经发育不良有关，包括精神运动发育、外化行为和综合发育。然而，关于其对其他神经学结局影响的确凿证据仍然有限。此外，还发现了对社会行为和睡眠问题的性别特异性影响。
