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The Practice of Enteral Nutrition: Clinical Evidence for Feeding Protocols.肠内营养实践：喂养方案的临床证据。
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Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.缓慢增加肠内喂养量以预防极低出生体重儿坏死性小肠结肠炎
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Early versus delayed initiation of progressive enteral feedings for parenterally fed low birth weight or preterm infants.经肠道外营养的低出生体重或早产儿早期与延迟开始渐进性肠内喂养的比较。
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Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.缓慢增加肠内喂养量以预防极低出生体重儿坏死性小肠结肠炎
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Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants.延迟引入渐进性肠内喂养以预防极低出生体重儿坏死性小肠结肠炎。
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Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.缓慢增加肠内喂养量以预防极低出生体重儿坏死性小肠结肠炎
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Early full enteral nutrition with fortified milk in very preterm infants: a randomized clinical trial.极早产儿早期使用强化牛奶进行全肠内营养：一项随机临床试验。
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Nutritional Strategies for Preterm Neonates and Preterm Neonates Undergoing Surgery: New Insights for Practice and Wrong Beliefs to Uproot.早产儿和手术中早产儿的营养策略：实践的新见解和需要摒弃的错误观念。
Nutrients. 2024 May 31;16(11):1719. doi: 10.3390/nu16111719.

本文引用的文献

1
Feeding tube practices and the colonisation of the preterm stomach in the first week of life.出生后第一周的喂养管操作与早产儿胃定植情况
Dan Med J. 2022 Jul 13;69(8):A06210494.
2
Association between duration of early empiric antibiotics and necrotizing enterocolitis and late-onset sepsis in preterm infants: a multicenter cohort study.早产儿早期经验性抗生素使用时间与坏死性小肠结肠炎和晚发性败血症的关系：一项多中心队列研究。
Eur J Pediatr. 2022 Oct;181(10):3715-3724. doi: 10.1007/s00431-022-04579-5. Epub 2022 Aug 4.
3
Efficacy and Safety of Enteral Recombinant Human Insulin in Preterm Infants: A Randomized Clinical Trial.肠内重组人生长激素在早产儿中的疗效和安全性：一项随机临床试验。
JAMA Pediatr. 2022 May 1;176(5):452-460. doi: 10.1001/jamapediatrics.2022.0020.
4
Spontaneous intestinal perforation (SIP) will soon become the most common form of surgical bowel disease in the extremely low birth weight (ELBW) infant.自发性肠穿孔（SIP）很快将成为极低出生体重（ELBW）婴儿中最常见的外科肠道疾病形式。
J Perinatol. 2022 Apr;42(4):423-429. doi: 10.1038/s41372-022-01347-z. Epub 2022 Feb 17.
5
A quality improvement initiative to standardize time to initiation of enteral feeds after non-surgical necrotizing enterocolitis using a consensus-based guideline.一项质量改进倡议，旨在使用基于共识的指南标准化非手术性坏死性小肠结肠炎后开始肠内喂养的时间。
J Perinatol. 2022 Apr;42(4):522-527. doi: 10.1038/s41372-022-01324-6. Epub 2022 Jan 28.
6
Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants.延迟经肠道给予逐渐增量喂养以预防极低出生体重儿坏死性小肠结肠炎。
Cochrane Database Syst Rev. 2022 Jan 20;1(1):CD001970. doi: 10.1002/14651858.CD001970.pub6.
7
Association between timing of re-introduction of enteral feeding and short-term outcomes following laparotomy for necrotising enterocolitis.剖腹探查术治疗坏死性小肠结肠炎后重新开始肠内喂养的时机与短期结局的关系。
J Pediatr Surg. 2022 Jul;57(7):1331-1335. doi: 10.1016/j.jpedsurg.2021.09.006. Epub 2021 Sep 17.
8
Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.缓慢增加肠内喂养量以预防极低出生体重儿坏死性小肠结肠炎。
Cochrane Database Syst Rev. 2021 Aug 24;8(8):CD001241. doi: 10.1002/14651858.CD001241.pub8.
9
Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth.随机分配到持续气道正压通气或气管插管后极低出生体重儿的生长速度。
J Pediatr. 2021 Oct;237:148-153.e3. doi: 10.1016/j.jpeds.2021.06.026. Epub 2021 Jun 19.
10
High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants.高容量与标准容量肠内喂养以促进早产儿或低出生体重儿的生长。
Cochrane Database Syst Rev. 2021 Mar 9;3(3):CD012413. doi: 10.1002/14651858.CD012413.pub3.

肠内营养实践：喂养方案的临床证据。

The Practice of Enteral Nutrition: Clinical Evidence for Feeding Protocols.

机构信息

Division of Neonatology, Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, 1700 6th Avenue South Women & Infants Center Suite 9380, Birmingham, AL 35233, USA.

Division of Neonatology, Department of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, 1700 6th Avenue South Women & Infants Center Suite 9380, Birmingham, AL 35233, USA.

出版信息

Clin Perinatol. 2023 Sep;50(3):607-623. doi: 10.1016/j.clp.2023.04.005. Epub 2023 May 26.

DOI:10.1016/j.clp.2023.04.005
PMID:37536767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10599301/
Abstract

Establishing full enteral nutrition in critically ill preterm infants with immature gastrointestinal function is challenging. In this article, we will summarize emerging clinical evidence from randomized clinical trials suggesting the feasibility and efficacy of feeding interventions targeting the early establishment of full enteral nutrition. We will also examine trial outcomes of higher volume feedings after the establishment of full enteral nutrition. Only data from randomized clinical trials will be discussed extensively. Future opportunities for clinical research will also be presented.

摘要

在胃肠道功能不成熟的危重症早产儿中建立完全肠内营养具有挑战性。本文总结了来自随机临床试验的新的临床证据，这些证据表明针对早期建立完全肠内营养的喂养干预措施具有可行性和有效性。我们还将检查完全肠内营养建立后增加喂养量的试验结果。本文将详细讨论仅来自随机临床试验的数据。还将介绍未来临床研究的机会。