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定义和评估人脚跟的有限元模型,以预防剪切载荷下的糖尿病足溃疡。

Definition and evaluation of a finite element model of the human heel for diabetic foot ulcer prevention under shearing loads.

机构信息

Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000, Grenoble, France.

Univ. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC, 38000, Grenoble, France.

出版信息

Med Eng Phys. 2023 Aug;118:104022. doi: 10.1016/j.medengphy.2023.104022. Epub 2023 Jul 11.

DOI:10.1016/j.medengphy.2023.104022
PMID:37536842
Abstract

Diabetic foot ulcers are triggered by mechanical loadings applied to the surface of the plantar skin. Strain is considered to play a crucial role in relation to ulcer etiology and can be assessed by Finite Element (FE) modeling. A difficulty in the generation of these models is the choice of the soft tissue material properties. In the literature, many studies attempt to model the behavior of the heel soft tissues by implementing constitutive laws that can differ significantly in terms of mechanical response. Moreover, current FE models lack of proper evaluation techniques that could estimate their ability to simulate realistic strains. In this article, we propose and evaluate a FE model of the human heel for diabetic foot ulcer prevention. Soft tissue constitutive laws are defined through the fitting of experimental stretch-stress curves published in the literature. The model is then evaluated through Digital Volume Correlation (DVC) based on non-rigid 3D Magnetic Resonance Image Registration. The results from FE analysis and DVC show similar strain locations in the fat pad and strain intensities according to the type of applied loads. For additional comparisons, different sets of constitutive models published in the literature are applied into the proposed FE mesh and simulated with the same boundary conditions. In this case, the results in terms of strains show great diversity in locations and intensities, suggesting that more research should be developed to gain insight into the mechanical properties of these tissues.

摘要

糖尿病足溃疡是由足底皮肤表面的机械负荷引起的。应变被认为与溃疡的病因有关,并且可以通过有限元(FE)建模来评估。生成这些模型的一个困难是软组织材料特性的选择。在文献中,许多研究试图通过实施本构定律来模拟足跟软组织的行为,这些本构定律在力学响应方面可能有很大的不同。此外,目前的 FE 模型缺乏适当的评估技术,无法估计其模拟真实应变的能力。在本文中,我们提出并评估了一种用于糖尿病足溃疡预防的人体足跟 FE 模型。通过拟合文献中公布的实验拉伸-应力曲线来定义软组织本构定律。然后,通过基于非刚性 3D 磁共振图像配准的数字体素来评估该模型。FE 分析和 DVC 的结果显示,在脂肪垫中的应变位置和应变强度与施加的载荷类型相似。为了进行额外的比较,将文献中公布的不同本构模型集应用于所提出的 FE 网格,并在相同的边界条件下进行模拟。在这种情况下,应变的结果在位置和强度上存在很大的差异,这表明应该进行更多的研究来深入了解这些组织的力学特性。

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