Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Surg Pathol Clin. 2023 Sep;16(3):533-548. doi: 10.1016/j.path.2023.04.008. Epub 2023 Jun 9.
Pathologists face many challenges when diagnosing sclerosing biliary lesions on liver biopsy. First, histologic findings tend to be nonspecific with similar to identical features seen in numerous conditions, from benign to outright malignant. In addition, the patchy nature of many of these entities amplifies the inherent limitations of biopsy sampling. The end result often forces pathologists to issue descriptive sign outs that require careful clinical correlation; however, certain clinical, radiologic, and histologic features may be of diagnostic assistance. In this article, we review key elements of four sclerosing biliary processes whose proper identification has significant prognostic and therapeutic implications.
病理学家在诊断肝活检中的硬化性胆管病变时面临许多挑战。首先，组织学发现往往是非特异性的，与许多良性到恶性疾病中所见的特征相似或相同。此外，这些病变的斑块状性质放大了活检取样固有的局限性。最终结果往往迫使病理学家发出需要仔细临床关联的描述性报告，但某些临床、放射学和组织学特征可能具有诊断帮助。在本文中，我们回顾了四种硬化性胆管过程的关键要素，正确识别这些过程具有重要的预后和治疗意义。
