Department of Physical Examination Center, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hanghzou, China.
Department of Clinical Laboratory, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hanghzou, 311202, China.
Sci Rep. 2023 Aug 3;13(1):12581. doi: 10.1038/s41598-023-39440-8.
Lung cancer ranks as one of the top malignancies and the leading cause of cancer death in both males and females in the US. Using a cancer database covering the entire population, this study was to determine the gender disparities in lung cancer incidence during 2001-2019. Cancer patients were obtained from the National Program of Cancer Registries (NPCR) and Surveillance, Epidemiology and End Results (SEER) database. The SEER*Stat software was applied to calculate the age-adjusted incidence rates (AAIR). Temporal changes in lung cancer incidence were analyzed by the Joinpoint software. A total of 4,086,432 patients (53.3% of males) were diagnosed with lung cancer. Among them, 52.1% were 70 years or older, 82.7% non-Hispanic white, 39.7% from the South, and 72.6% non-small cell lung cancer (NSCLC). The AAIR of lung cancer continuously reduced from 91.0 per 100000 to 59.2 in males during the study period, while it increased from 55.0 in 2001 to 56.8 in 2006 in females, then decreased to 48.1 in 2019. The female to male incidence rate ratio of lung cancer continuously increased from 2001 to 2019. Gender disparities were observed among age groups, races, and histological types. In those aged 0-54 years, females had higher overall incidence rates of lung cancer than males in recent years, which was observed in all races (except non-Hispanic black), all regions, and adenocarcinoma and small cell (but not squamous cell). Non-Hispanic black females aged 0-54 years had a faster decline rate than males since 2013. API females demonstrated an increased trend during the study period. Lung cancer incidence continues to decrease with gender disparities among age groups, races, regions, and histological types. Continuous anti-smoking programs plus reduction of related risk factors are necessary to lower lung cancer incidence further.
肺癌是美国男性和女性中排名最高的恶性肿瘤之一，也是癌症死亡的主要原因。本研究使用涵盖全人群的癌症数据库，旨在确定 2001-2019 年期间肺癌发病率的性别差异。癌症患者来自国家癌症登记处（NPCR）和监测、流行病学和最终结果（SEER）数据库。应用 SEER*Stat 软件计算年龄调整发病率（AAIR）。使用 Joinpoint 软件分析肺癌发病率的时间变化。共诊断出 4086432 例（53.3%为男性）肺癌患者。其中，52.1%为 70 岁或以上，82.7%为非西班牙裔白人，39.7%来自南部，72.6%为非小细胞肺癌（NSCLC）。研究期间，男性肺癌 AAIR 从 91.0/100000 持续下降至 59.2/100000，而女性则从 2001 年的 55.0/100000 增加至 2006 年的 56.8/100000，然后在 2019 年降至 48.1/100000。女性肺癌发病率与男性的比值从 2001 年持续增加到 2019 年。在年龄组、种族和组织学类型中观察到性别差异。在 0-54 岁年龄组中，近年来女性肺癌总发病率高于男性，在所有种族（非西班牙裔黑种人除外）、所有地区以及腺癌和小细胞癌（而非鳞状细胞癌）中均观察到这种情况。自 2013 年以来，0-54 岁非西班牙裔黑人女性的下降速度快于男性。亚太裔女性在研究期间呈上升趋势。肺癌发病率继续下降，不同年龄组、种族、地区和组织学类型的性别差异仍然存在。需要继续开展控烟项目并减少相关危险因素，以进一步降低肺癌发病率。
