Muggia-Sullam M, Matarese L E, Edwards L L, Fischer J E
JPEN J Parenter Enteral Nutr. 1986 Jan-Feb;10(1):45-8. doi: 10.1177/014860718601000145.
The efficacy and side effects of two elemental diets were studied. Twenty young Sprague-Dawley rats were fed one of three different diets. Group I (n = 7) was fed Vivonex-HN (VIV) ad lib; group II (n = 7) was given Criticare-HN (CRI), pair-fed to group I (the two elemental diets were given in glass bottles); group III was fed regular rat chow and served as control (CON). Body weight (WT), food intake, and nitrogen balance (NB) were measured daily. After 21 days, change in body weight was similar in the three groups (VIV = 64.9 +/- 3.2%; CRI = 59.6 +/- 3.3%; CON = 63.9 +/- 4.8%). Cumulative nitrogen balance was also similar in the two groups fed elemental diets (VIV = 4788 +/- 277 mg N; CRI = 4690 +/- 118 mg N), but in both these groups it was less than the control group fed chow (8060 +/- 85 mg N). Blood urea nitrogen (BUN) on the last day was higher in the VIV group (12.9 +/- 1.22 mg/dl) than in the CRI group (9.43 +/- 0.43 mg/dl), but in both study groups it was lower than in the CON group (17.2 +/- 1.08 mg/dl), although nitrogen intake was higher in the control (ad lib) group. SGPT was similar in the two elemental diets but higher than in CON. Liver weights were higher in the CRI group, probably abnormally so and likely due to increased fat content. Both diets had similar efficacy in nutritional support.
研究了两种要素饮食的疗效和副作用。将20只年轻的斯普拉格-道利大鼠分为三组，分别喂食不同的饮食。第一组（n = 7）自由采食Vivonex-HN（VIV）；第二组（n = 7）给予Criticare-HN（CRI），与第一组进行配对喂食（两种要素饮食均装在玻璃瓶中）；第三组喂食常规大鼠饲料，作为对照组（CON）。每天测量体重（WT）、食物摄入量和氮平衡（NB）。21天后，三组的体重变化相似（VIV = 64.9 +/- 3.2%；CRI = 59.6 +/- 3.3%；CON = 63.9 +/- 4.8%）。喂食要素饮食的两组累积氮平衡也相似（VIV = 4788 +/- 277 mg N；CRI = 4690 +/- 118 mg N），但这两组的氮平衡均低于喂食普通饲料的对照组（8060 +/- 85 mg N）。最后一天，VIV组的血尿素氮（BUN）（12.9 +/- 1.22 mg/dl）高于CRI组（9.43 +/- 0.43 mg/dl），但两个研究组的BUN均低于CON组（17.2 +/- 1.08 mg/dl），尽管对照组（自由采食）的氮摄入量更高。两种要素饮食组的谷丙转氨酶（SGPT）相似，但高于CON组。CRI组的肝脏重量较高，可能不正常，可能是由于脂肪含量增加。两种饮食在营养支持方面具有相似的疗效。
