Division of Practical Pharmacy.
Division of Pharmacodynamics.
Pharmazie. 2023 Jul 1;78(6):86-88. doi: 10.1691/ph.2023.3528.
S-Carboxymethyl-L-cysteine (SCMS) exhibits sputum-regulating and anti-inflammatory actions. Previous studies reported the anti-inflammatory effects of SCMS on chronic inflammatory diseases, but no study has examined these effects on acute inflammatory diseases. In this study, we investigated the anti-inflammatory effects of SCMS in a rat carrageenan-induced footpad edema model, which is routinely used as an acute inflammation model. Expectorants were administered to rats with footpad edema induced by subcutaneously administering 1%λ-carrageenan to the footpad of the left posterior limb, and the dose dependency of the anti-inflammatory effects was evaluated. As a result, even when the dose of SCMS was increased to 400 mg/kg, there were no inhibitory effects on edema. Furthermore, we examined the inhibitory effects of other expectorants (ambroxol hydrochloride, N-acetyl-L-cysteine, L-cysteine ethylester hydrochloride, and L-cysteine methylester hydrochloride), which were reported to exhibit anti-inflammatory effects on chronic inflammation, on edema. However, none of these expectorants inhibited edema.
S-羧甲基-L-半胱氨酸（SCMS）具有化痰和抗炎作用。先前的研究报告了 SCMS 对慢性炎症性疾病的抗炎作用，但尚无研究检查其对急性炎症性疾病的这些作用。在这项研究中，我们在角叉菜胶诱导的大鼠足垫水肿模型中研究了 SCMS 的抗炎作用，该模型通常用作急性炎症模型。向经皮向左侧后肢足垫皮下注射 1%λ-角叉菜胶诱导足垫水肿的大鼠给予化痰药，并评估抗炎作用的剂量依赖性。结果，即使 SCMS 的剂量增加到 400mg/kg，也没有对水肿产生抑制作用。此外，我们还检查了其他化痰药（盐酸氨溴索、N-乙酰-L-半胱氨酸、L-半胱氨酸乙酯盐酸盐和 L-半胱氨酸甲酯盐酸盐）对水肿的抑制作用，这些化痰药据报道对慢性炎症具有抗炎作用。然而，这些化痰药均未抑制水肿。
