Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Department of Pharmacy, Changzhi Medical University, Changzhi 046000, China.
ACS Appl Mater Interfaces. 2023 Aug 16;15(32):38264-38272. doi: 10.1021/acsami.3c06353. Epub 2023 Aug 3.
Given that light is hard to reach deep tumor tissue, how to enhance photodynamic therapy (PDT) efficacy is a big challenge. Herein, we proposed the supramolecular polymer self-assemblies (HACP) with bis[2,4,5-trichloro-6 (pentyloxycar-bonyl) phenyl] oxalate as the cargos (HACP@CPPO) to realize the chemiluminescence resonance energy transfer (CRET)-induced generation of O in situ. HACP was prepared by cinnamaldehyde-modified hyaluronic acid (HA-CA) and β-cyclodextrin-modified protoporphyrin IX (β-CD-PPIX) via host-guest interactions. The CA moiety could elevate HO levels for the enhanced production of chemical energy and macrocyclic CD could enhance the stacking distance of PPIX for enhanced O yield. Thus, HACP@CPPO exhibited excellent antitumor performance without light irradiation.
鉴于光是难以到达深层肿瘤组织的，如何增强光动力疗法（PDT）的疗效是一个巨大的挑战。在此，我们提出了具有双[2,4,5-三氯-6（戊氧基羰基）苯基]草酸酯作为有效载荷的超分子聚合物自组装体（HACP）（HACP@CPPO），以实现化学发光共振能量转移（CRET）诱导的原位 O 生成。HACP 通过肉桂醛修饰的透明质酸（HA-CA）和β-环糊精修饰的原卟啉 IX（β-CD-PPIX）通过主客体相互作用制备。CA 部分可以提高 HO 水平，以增强化学能量的产生，而大环 CD 可以增加 PPIX 的堆积距离，以提高 O 的产量。因此，HACP@CPPO 在没有光照的情况下表现出了优异的抗肿瘤性能。
