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前蛋白转化酶枯草溶菌素9抑制剂对代谢相关脂肪性肝病的影响:简短综述

Effects of PCSK9 inhibitors on metabolic-associated fatty liver disease: a short review.

作者信息

Jakielska Ewelina, Głuszak Paweł, Walczak Marta, Bryl Wiesław

机构信息

Student Internal Medicine Research Society, Poznan University of Medical Sciences, Poznan, Poland.

Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Prz Gastroenterol. 2023;18(2):148-153. doi: 10.5114/pg.2023.126054. Epub 2023 Mar 23.

Abstract

Metabolic-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is a significant epidemiological problem and a well-known cardiovascular risk factor. The increasing number of cases creates the need for new therapeutic methods aimed at improving patient outcomes. Recent studies have highlighted the relationship between MAFLD and proprotein convertase subtilisin/kexin type 9 (PCSK9). Based on the available data, PCSK9 inhibitors appear to have beneficial effects in patients with MAFLD, and they may be a treatment option in the future. Further research is necessary to better evaluate the efficiency of PCSK9 inhibitors in MAFLD treatment.

摘要

代谢相关脂肪性肝病(MAFLD),以前称为非酒精性脂肪性肝病,是一个重大的流行病学问题,也是一个众所周知的心血管危险因素。病例数量的增加使得需要新的治疗方法来改善患者预后。最近的研究强调了MAFLD与前蛋白转化酶枯草杆菌蛋白酶/kexin 9型(PCSK9)之间的关系。根据现有数据,PCSK9抑制剂似乎对MAFLD患者有有益作用,并且它们可能是未来的一种治疗选择。有必要进行进一步研究,以更好地评估PCSK9抑制剂在MAFLD治疗中的疗效。

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