Lacouture P G, Gaudreault P, Lovejoy F H
Ann Emerg Med. 1986 Feb;15(2):143-6. doi: 10.1016/s0196-0644(86)80008-7.
To help establish a rational approach to the initial management of Clinitest tablet ingestion, we investigated the effect of number of tablets, volume of diluent, and type of diluent on dissolution time (TD), temperature generation (delta T), and pH. Dissolution time was independent of the number of tablets and the volume of fluid; however, it was dependent on the type of fluid used. The thermal generation (delta T) was dependent on the number of tablets and volume of fluid, but was independent of the type of fluid used. The pH changes were independent of the number of tablets and volume of fluid; however, they were greatly dependent on the type of fluid. These data suggest that dissolution is rapid (in seconds) and, therefore, the most effective intervention may occur shortly after ingestion of the tablets; the larger the volume of diluting fluid, the smaller the risk of thermal damage from these ingestions; and orange juice should be considered as a possible diluent because it is capable of reducing the pH of the Clinitest tablet without increasing thermal generation.
为了帮助建立对Clinitest片剂摄入初始管理的合理方法，我们研究了片剂数量、稀释剂体积和稀释剂类型对溶解时间（TD）、温度升高（ΔT）和pH值的影响。溶解时间与片剂数量和液体体积无关；然而，它取决于所用液体的类型。热生成（ΔT）取决于片剂数量和液体体积，但与所用液体的类型无关。pH值变化与片剂数量和液体体积无关；然而，它们很大程度上取决于所用液体的类型。这些数据表明溶解迅速（在数秒内），因此，最有效的干预可能在摄入片剂后不久发生；稀释液体积越大，这些摄入导致热损伤的风险越小；橙汁应被视为一种可能的稀释剂，因为它能够降低Clinitest片剂的pH值而不增加热生成。
