Martic Vesna, Fejzic Esmer, Danilovic Milos, Lazarevic Snezana, Rajic Sonja, Roganovic Milovan, Stojanov Aleksanar, Jovin Zita, Debeljevic Mladen, Raicevic Ranko
Military Medical Academy, Clinic of Neurology, Belgrade, Serbia.
Department of Neurology, University of Kragujevac, Serbia, Faculty of Medical Sciences, Kragujevac, Serbia.
Ann Indian Acad Neurol. 2023 May-Jun;26(3):256-260. doi: 10.4103/aian.aian_974_22. Epub 2023 Apr 20.
Guillain-Barré syndrome (GBS) is usually triggered by an infection. Vaccination is mentioned as a possible trigger in a small number of GBS cases. The aim of this study was to notice GBS distinctness provoked by various triggers during the COVID-19 pandemic.
A total of 109 GBS patients were divided into three groups, respectively: COVID-19 infection associated (19 patients), COVID-19 vaccination associated (16 patients) and precipitated by some other factors (74 patients). We compared the clinical, neurophysiological and laboratory characteristics of these three groups.
Neither were differences recorded in the age of the patients of these three groups at the time of illness, nor in the number of days from the precipitating factor to the onset of symptoms. There were no clinical differences between groups related to severity of the disease or patients' recovery. The only clinical difference was observed in relation to facial nerve bilateral affection because it was significantly higher in the post-vaccination group. According to neurophysiological findings, demyelinating form dominated in all three groups.
Clinical characteristics, electrophysiological findings and laboratory characteristics did not differ significantly in Guillain-Barre syndrome followed by COVID-19 infection, vaccination and other precipitating factors during the pandemic. The bilateral involvement of facial nerves was significantly higher in the post-vaccination group. Most of these cases had a mild form of the disorder-distal paresthesias GBS variant.
吉兰-巴雷综合征（GBS）通常由感染引发。在少数GBS病例中，疫苗接种被提及为一种可能的触发因素。本研究的目的是观察在新冠疫情期间由各种触发因素引发的GBS的特点。
总共109例GBS患者被分为三组，分别为：与新冠感染相关（19例患者）、与新冠疫苗接种相关（16例患者）以及由其他一些因素引发（74例患者）。我们比较了这三组患者的临床、神经生理学和实验室特征。
这三组患者发病时的年龄以及从触发因素到症状出现的天数均无差异。在疾病严重程度或患者恢复情况方面，各组之间没有临床差异。唯一观察到的临床差异与双侧面神经受累有关，因为在疫苗接种后组中该情况显著更高。根据神经生理学结果，脱髓鞘型在所有三组中均占主导。
在疫情期间，由新冠感染、疫苗接种和其他触发因素引发的吉兰-巴雷综合征在临床特征、电生理结果和实验室特征方面没有显著差异。疫苗接种后组中面神经的双侧受累显著更高。这些病例大多数为该疾病的轻症形式——远端感觉异常型GBS。
