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计算机交互式形态测量法作为非霍奇金淋巴瘤分类的一种潜在有用工具。

Computerized interactive morphometry as a potentially useful tool for the classification of non-Hodgkin's lymphomas.

作者信息

Marchevsky A, Gil J, Silage D

出版信息

Cancer. 1986 Apr 15;57(8):1544-9. doi: 10.1002/1097-0142(19860415)57:8<1544::aid-cncr2820570818>3.0.co;2-4.

Abstract

The use of a simple form of Computerized Interactive Morphometry (CIM) is proposed as a tool to achieve a reproducible classification of non-Hodgkin's lymphomas. This system combines a random sampling method for cells with simple size measurements and additional subjective criteria such as a shape, mitotic counts, and follicular or diffuse features. In this system, which utilizes a high resolution touch screen as interactive peripheral, the video image of the specimen is superimposed to a computer generated reference system which consists of a test area and four fixed points for random sampling of cells and a series of concentric circles to serve as internal standard for nuclear size; the computer tabulates and facilitates data processing. Forty-four lymphoid lesions have been characterized with the CIM system and specific criteria for diagnoses according to the Working Formulation of non-Hodgkin's lymphomas for clinical usage are derived. Studies of inter- and intraobserver variations in data collection are discussed, and a diagnostic algorithm that categorizes non-Hodgkin's lymphomas according to the relative proportions of various lymphoid cells and densities of mitotic counts is proposed. The potential applications of touch screen-based CIM for the study of malignant lymphomas and its practical technical advantages over other quantitative systems based on either gray-level analysis or tracings of cell contours on photographs or digitizer pads are emphasized.

摘要

有人提出使用一种简单形式的计算机交互式形态测量法(CIM)作为对非霍奇金淋巴瘤进行可重复分类的工具。该系统将细胞随机抽样方法与简单的大小测量以及其他主观标准(如形状、有丝分裂计数和滤泡或弥漫性特征)相结合。在这个利用高分辨率触摸屏作为交互式外围设备的系统中,标本的视频图像叠加到一个计算机生成的参考系统上,该参考系统由一个测试区域、四个用于细胞随机抽样的固定点以及一系列同心圆组成,这些同心圆用作核大小的内标;计算机对数据进行列表并便于数据处理。已使用CIM系统对44个淋巴样病变进行了特征描述,并得出了根据非霍奇金淋巴瘤工作方案用于临床的诊断具体标准。讨论了观察者间和观察者内数据收集的差异研究,并提出了一种根据各种淋巴样细胞的相对比例和有丝分裂计数密度对非霍奇金淋巴瘤进行分类的诊断算法。强调了基于触摸屏的CIM在恶性淋巴瘤研究中的潜在应用及其相对于其他基于灰度分析或在照片或数字化仪板上描绘细胞轮廓的定量系统的实际技术优势。

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