Peng Yi-Fan, Wang Lin-Lin, Gu Juan-Hua, Zeng Yue-Qin
Academy of Biomedical Engineering, Kunming Medical University, Kunming, 650500, China.
Heliyon. 2023 Jul 17;9(7):e18288. doi: 10.1016/j.heliyon.2023.e18288. eCollection 2023 Jul.
Major depressive disorder (MDD) is a prevalent psychiatric condition that results in persistent feelings of sadness and loss of interest, imposing a significant economic burden on health systems and society. Impaired sleep is both a symptom and a risk factor for depression. Natural astaxanthin (AST), a carotenoid primarily derived from algae and aquatic animals, possesses multiple pharmacological properties such as anti-inflammatory, anti-apoptotic, and antioxidant stress effects. Prior research suggests that AST may have antidepressant properties. This mini-review highlights the potential mechanisms by which AST can prevent depression, providing novel insights into drug research for depression treatment. Specifically, this mechanism suggests that astaxanthin may improve sleep and thus potentially aid in the treatment of depression.
重度抑郁症（MDD）是一种常见的精神疾病，会导致持续的悲伤情绪和兴趣丧失，给卫生系统和社会带来巨大的经济负担。睡眠障碍既是抑郁症的症状，也是其风险因素。天然虾青素（AST）是一种主要来源于藻类和水生动物的类胡萝卜素，具有多种药理特性，如抗炎、抗凋亡和抗氧化应激作用。先前的研究表明，AST可能具有抗抑郁特性。这篇综述强调了AST预防抑郁症的潜在机制，为抑郁症治疗的药物研究提供了新的见解。具体而言，该机制表明虾青素可能改善睡眠，从而潜在地有助于抑郁症的治疗。
