虾青素的抗炎作用及其在治疗各种疾病中的应用。

Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases.

机构信息

Department of Biology, Faculty of Sciences, University of Tehran, Iran.

Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran; Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran.

出版信息

Biomed Pharmacother. 2022 Jan;145:112179. doi: 10.1016/j.biopha.2021.112179. Epub 2021 Nov 1.

DOI:10.1016/j.biopha.2021.112179

PMID:34736076

Abstract

Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize the available literature on the anti-inflammatory efficacy of AST in various chronic and acute disorders, such as neurodegenerative, renal-, hepato-, skin- and eye-related diseases, as well as gastrointestinal disorders. In addition, we elaborated on therapeutic efficacy of AST and the role of several pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3 in mediating its effects. However, additional experimental and clinical studies should be performed to corroborate the anti-inflammatory effects and protective effects of AST against inflammatory diseases in humans. Nevertheless, this review suggests that AST with its demonstrated anti-inflammatory property may be a suitable candidate for drug design with novel technology.

摘要

虾青素（AST）是一种红色类胡萝卜素，具有显著的抗氧化、抗炎、抗增殖和抗凋亡特性。在这项研究中，我们总结了关于 AST 在各种慢性和急性疾病中的抗炎功效的现有文献，如神经退行性疾病、肾、肝、皮肤和眼部疾病以及胃肠道疾病。此外，我们详细阐述了 AST 的治疗功效以及几种途径的作用，包括 PI3K/AKT、Nrf2、NF-κB、ERK1/2、JNK、p38 MAPK 和 JAK-2/STAT-3，这些途径介导了其作用。然而，应该进行更多的实验和临床研究来证实 AST 对人类炎症性疾病的抗炎作用和保护作用。尽管如此，本综述表明，AST 具有抗炎特性，可能是使用新技术进行药物设计的合适候选药物。