Neamatallah Thikryat
Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Heliyon. 2023 Jul 17;9(7):e18274. doi: 10.1016/j.heliyon.2023.e18274. eCollection 2023 Jul.
Hypersensitivity reactions can be a side effect to any vaccine, but they are usually rare. The COVID-19 vaccination may cause hypersensitivity, and several cases of delayed hypersensitivity (DH) to hyaluronic acid (HA) dermal filler have been documented. The current report presents a case of a 36-year-old female patient with DH to HA dermal filler after receiving the Pfizer-BioNTech COVID-19 vaccine. Symptoms, including dryness, swelling, and a painless nodule, appeared after the first and second doses of the vaccine. The patient was treated with intralesional hyaluronidase and triamcinolone in the outpatient clinic. Although HA is relatively safe and routinely used in aesthetic medicine, DH reactions must be considered. Therefore, an appropriate patient history should be obtained, and physicians should provide counselling on the potential reactions to avoid these adverse effects.
超敏反应可能是任何疫苗的副作用，但通常很少见。新冠疫苗接种可能会引起超敏反应，并且已经有几例关于对透明质酸（HA）真皮填充剂发生迟发性超敏反应（DH）的记录。本报告介绍了一名36岁女性患者，在接种辉瑞- BioNTech新冠疫苗后对HA真皮填充剂发生迟发性超敏反应的病例。在接种第一剂和第二剂疫苗后出现了包括干燥、肿胀和无痛性结节在内的症状。该患者在门诊接受了病灶内注射透明质酸酶和曲安奈德的治疗。虽然HA相对安全且常用于美容医学，但必须考虑迟发性超敏反应。因此，应获取适当的患者病史，医生应就潜在反应提供咨询，以避免这些不良反应。
