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针对急性A型主动脉夹层中由于主动脉弓上分支血管严重狭窄或闭塞导致的术前脑灌注不良的解剖外血管重建及新的插管策略

Extra-anatomic revascularization and a new cannulation strategy for preoperative cerebral malperfusion due to severe stenosis or occlusion of supra-aortic branch vessels in acute type A aortic dissection.

作者信息

Sun Jingwei, Xue Chao, Zhang Jinglong, Yang Chen, Ren Kai, Zhu Hanzhao, Zhang Bin, Li Xiayun, Zhao Hongliang, Jin Zhenxiao, Liu Jincheng, Duan Weixun

机构信息

Department of Cardiovascular Surgery, The First Affiliated Hospital, The Air Force Medical University, Xi'an, Shaanxi, China.

Department of Cardiovascular Surgery, Xijing Hospital, The Air Force Medical University, Xi'an, Shaanxi, China.

出版信息

Heliyon. 2023 Jul 15;9(7):e18251. doi: 10.1016/j.heliyon.2023.e18251. eCollection 2023 Jul.

DOI:10.1016/j.heliyon.2023.e18251
PMID:37539273
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10395476/
Abstract

OBJECTIVES

Acute type A aortic dissection (ATAAD) with severe stenosis or occlusion of the true lumen of aortic arch branch vessels often leads to an increased incidence of severe postsurgical neurological complications and mortality rate. In this study, we aimed to introduce our institutional extra-anatomic revascularization and cannulation strategy with improved postoperative outcomes for better management of patients with cerebral malperfusion in the setting of ATAAD.

METHODS

Twenty-eight patients with ATAAD complicated by severe stenosis or occlusion of the aortic arch branch vessels, as noted on combined computed tomography angiography of the aorta and craniocervical artery, between January 2021 and June 2022 were included in this study. Basic patient characteristics, surgical procedures, hospitalization stays, and early follow-up results were analyzed.

RESULTS

The median follow-up duration was 16.5 months (interquartile range: 11.5-20.5), with a 100% completion rate. The 30-day mortality rates was 7.1% (2/28 patients); two patients had multiple cerebral infarctions on preoperative computed tomography and persistent coma. Postoperative transient neurological dysfunction occurred in 10.7% (3/28) of the patients, and no new permanent neurological dysfunction occurred. Of all the patients, 3.6% (1/28) had novel acute renal failure. No other deaths, secondary surgeries, or serious complications occurred during the early follow-up period.

CONCLUSIONS

Use of extra-anatomic revascularization and a new cannulation strategy before cardiopulmonary bypass is safe and feasible and may reduce the high incidence of postoperative neurological complications in patients with ATAAD and cerebral malperfusion.

摘要

目的

急性A型主动脉夹层(ATAAD)合并主动脉弓分支血管真腔严重狭窄或闭塞常导致术后严重神经并发症发生率和死亡率增加。在本研究中,我们旨在介绍我院的解剖外血管重建和插管策略,以改善术后结局,从而更好地管理ATAAD合并脑灌注不良的患者。

方法

本研究纳入了2021年1月至2022年6月期间28例经主动脉和颅颈动脉联合计算机断层血管造影显示ATAAD合并主动脉弓分支血管严重狭窄或闭塞的患者。分析患者的基本特征、手术过程、住院时间和早期随访结果。

结果

中位随访时间为16.5个月(四分位间距:11.5~20.5),完成率为100%。30天死亡率为7.1%(2/28例患者);2例患者术前计算机断层扫描显示多发性脑梗死且持续昏迷。10.7%(3/28)的患者术后出现短暂性神经功能障碍,未出现新的永久性神经功能障碍。所有患者中,3.6%(1/28)出现新发急性肾衰竭。在早期随访期间未发生其他死亡、二次手术或严重并发症。

结论

在体外循环前采用解剖外血管重建和新的插管策略是安全可行的,可能会降低ATAAD合并脑灌注不良患者术后神经并发症的高发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/af4011838557/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/2ec980bccf4b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/ecefc3ea465b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/af4011838557/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/2ec980bccf4b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/ecefc3ea465b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b791/10395476/af4011838557/gr3.jpg

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