National Skin Centre, Singapore, Singapore.
Skin Tree Center, Shah Alam, Malaysia.
Int J Cosmet Sci. 2023 Dec;45(6):769-774. doi: 10.1111/ics.12885. Epub 2023 Aug 14.
Dandruff is a common scalp condition affecting almost half of the world's population. Despite its high prevalence, the exact pathophysiology is not well established and is understood to be multifactorial, with factors such as fungal colonization, sebaceous gland activity and individual factors being implicated. There is a need for an effective and safe shampoo that can target the above factors. Hence, we have developed a shampoo formulation with properties of oil control, moisturizing, non-irritative, anti-fungal, anti-microbial and itch-relieving. In this interventional, open-label study, we evaluated the efficacy and safety of this shampoo in reducing the clinical signs of dandruff and pruritus in patients with pre-existing mild-to-moderate dandruff over a course of 21-day treatment duration through self-assessment and objective clinical evaluations. After continued use of the shampoo, there was a significant decrease in the adherent and loose scalp flaking scores. Mean pruritus scores also decreased significantly across the 21-day time points. There were also no adverse events or skin intolerances reported. This study showed that our shampoo formulation has led to a significant reduction in both adherent and loose scalp flaking and pruritus when used in individuals suffering from mild to moderate dandruff. As such, it is an ideal shampoo, which can be used to effectively control dandruff.
头皮屑是一种常见的头皮状况，影响着全世界近一半的人口。尽管其发病率很高，但确切的病理生理学机制尚未得到很好的确立，被认为是多因素的，涉及真菌定植、皮脂腺活动和个体因素等。因此，我们需要一种能够针对上述因素的有效且安全的洗发水。于是，我们开发了一种具有控油、保湿、无刺激性、抗真菌、抗菌和止痒特性的洗发水配方。在这项干预性、开放性标签研究中，我们通过自我评估和客观临床评估，评估了该洗发水在 21 天治疗过程中减轻已有轻度至中度头皮屑患者头皮屑和瘙痒临床症状的疗效和安全性。在继续使用洗发水后，附着性和松散性头皮鳞屑评分显著降低。瘙痒评分在 21 天的时间点也显著下降。也没有报告不良反应或皮肤不耐受。这项研究表明，我们的洗发水配方在治疗轻度至中度头皮屑患者时，可显著减少附着性和松散性头皮鳞屑和瘙痒。因此，它是一种理想的洗发水，可以有效地控制头皮屑。
