Faculty of Pharmacy, University Malaya, Kuala Lumpur, Malaysia.
University Malaya Centre for Addiction Science (UMCAS), Kuala Lumpur, Malaysia.
J Addict Dis. 2024 Oct-Dec;42(4):360-372. doi: 10.1080/10550887.2023.2240932. Epub 2023 Aug 4.
The emergence of New Psychoactive Substances (NPS), including synthetic psilocybin, has raised concern among health experts due to the numerous health and socioeconomic consequences. The current trend is shifting to the hazardous use of synthetic psilocybin in vaping, and little is known about the prevalence of use, specifically among amphetamine-type stimulants (ATS) users.
Interviewer-administered questionnaires were conducted in drug detention centers between March and October 2022. The study was conducted using ASSIST 3.0 and obtained information on the respondents' socio-demographic characteristics and clinical profiles. = 355 ATS users were enrolled in this study.
The results show a high prevalence of psilocybin vaping among ATS users (182/355, 53.1%). Most of the respondents were males (85.1%) and unmarried (69.3%), with a mean age of 29.2 (SD = 7.3). Across all respondents, five factors were associated with psilocybin vaping: tobacco smoking, aOR =5.790 (95% CI: 1.723, 8.183); cannabis uses, aOR= 9.152 (95% CI: 2.693, 10.396); and alcohol use, aOR= 3.137 (95% CI: 1.461, 5.817). Respondents of the Malay race had higher odds of being involved in psilocybin vaping compared to other races, with aOR= 1.638 (0.043, 2.459). Meanwhile, a reduction in age by 1.9 will increase the likelihood of involvement in psilocybin vaping with aOR = 1.897 (95% CI: 0.857, 1.938).
Psilocybin in vaping is growing among ATS users and across all populations. Unfortunately, knowledge regarding the long-term effects on health is limited. Further studies should highlight the harmful effects of psilocybin and the potential risk of psilocybin vaping among the younger population.
新精神活性物质（NPS）的出现，包括合成迷幻蘑菇，引起了健康专家的关注，因为它们会带来许多健康和社会经济方面的后果。目前的趋势是转向合成迷幻蘑菇在蒸气中的危险使用，而对于其使用情况，特别是在苯丙胺类兴奋剂（ATS）使用者中的流行程度，知之甚少。
在 2022 年 3 月至 10 月期间，在戒毒中心进行了访谈者管理的问卷调查。该研究使用 ASSIST 3.0 进行，获取了受访者社会人口统计学特征和临床特征的信息。共纳入 355 名 ATS 用户进行本研究。
结果显示，ATS 用户中迷幻蘑菇蒸气使用的流行率很高（182/355，53.1%）。大多数受访者为男性（85.1%）和未婚（69.3%），平均年龄为 29.2 岁（SD=7.3）。在所有受访者中，有五个因素与迷幻蘑菇蒸气使用相关：吸烟，aOR=5.790（95%CI：1.723，8.183）；使用大麻，aOR=9.152（95%CI：2.693，10.396）；和饮酒，aOR=3.137（95%CI：1.461，5.817）。与其他种族相比，马来族受访者参与迷幻蘑菇蒸气使用的可能性更高，aOR=1.638（0.043，2.459）。同时，年龄每减少 1.9 岁，参与迷幻蘑菇蒸气使用的可能性就会增加 aOR=1.897（95%CI：0.857，1.938）。
迷幻蘑菇蒸气在 ATS 用户和所有人群中的使用都在增加。不幸的是，关于其对健康的长期影响的知识有限。进一步的研究应该强调迷幻蘑菇的有害影响，以及迷幻蘑菇蒸气在年轻人群中的潜在风险。
