Soft tissue calcification: a complication of vitamin E injection.

Two cases of gross soft tissue calcification following intramuscular administration of vitamin E in two premature babies are described. The drug was administered for prevention of retinopathy of prematurity. The relation between this complication and both the dosage used and the duration of the treatment is discussed. In spite of the extent of the calcifications, a benign course was observed. Other reports about this complication are reviewed.