Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Biomed Pharmacother. 2023 Sep;165:115257. doi: 10.1016/j.biopha.2023.115257. Epub 2023 Aug 2.
Zinc finger protein 335 (ZNF335) plays a crucial role in the methylation and, consequently, regulates the expression of a specific set of genes. Variants of the ZNF335 gene have been identified as risk factors for microcephaly in a variety of populations worldwide. Meanwhile, ZNF335 has also been identified as an essential regulator of T-cell development. However, an in-depth understanding of the role of ZNF335 in brain development and T cell maturation is still lacking. In this review, we summarize current knowledge of the molecular mechanisms underlying the involvement of ZNF335 in neuronal and T cell development across a wide range of pre-clinical, post-mortem, ex vivo, in vivo, and clinical studies. We also review the current limitations regarding the study of the pathophysiological functions of ZNF335. Finally, we hypothesize a potential role for ZNF335 in brain disorders and discuss the rationale of targeting ZNF335 as a therapeutic strategy for preventing brain disorders.
锌指蛋白 335（ZNF335）在甲基化中发挥着关键作用，进而调控特定基因的表达。在全球范围内的各种人群中，ZNF335 基因的变异被鉴定为小头畸形的风险因素。同时，ZNF335 也被鉴定为 T 细胞发育的必需调节因子。然而，人们对 ZNF335 在大脑发育和 T 细胞成熟中的作用仍知之甚少。在这篇综述中，我们总结了 ZNF335 在神经和 T 细胞发育中涉及的分子机制的最新知识，这些知识来源于广泛的临床前、死后、离体、体内和临床研究。我们还回顾了目前研究 ZNF335 病理生理学功能的局限性。最后，我们假设 ZNF335 可能在脑疾病中发挥作用，并讨论了将 ZNF335 作为预防脑疾病的治疗策略的合理性。
