Indianapolis Zoo, Indianapolis, IN.
University of Tennessee, College of Veterinary Medicine, Knoxville, TN.
Am J Vet Res. 2023 Aug 8;84(10):1-4. doi: 10.2460/ajvr.23.06.0130. Print 2023 Sep 1.
To determine the pharmacokinetics of robenacoxib after a single intramuscular dose (4.0 mg/kg) in smooth dogfish (Mustelus canis).
8 healthy adult male smooth dogfish in human care within the same habitat.
All sharks received a single intramuscular dose of robenacoxib (4.0 mg/kg) in the right caudolateral epaxial musculature. Blood samples were collected under manual restraint from the ventral tail vessel at 30 minutes, 1 hour, 2 hours, 4 hours, 8 hours, and 24 hours after drug administration. Plasma drug concentrations were determined by HPLC followed by noncompartmental pharmacokinetic analysis of the data.
A maximum plasma concentration of 1.24 µg/mL was reached at a mean time of 30 minutes following robenacoxib administration with a plasma elimination half-life of 3.79 hours. Plasma concentrations did not fall below the lower limit of quantification (0.1 µg/mL) at the time points sampled in this study.
Intramuscular administration of a single dose (4.0 mg/kg) of robenacoxib in smooth dogfish resulted in rapid absorption to a maximum concentration at approximately 30 minutes after administration and persisted above levels considered to be therapeutic in domestic species for at least 8 hours.
确定单次肌肉注射（4.0mg/kg）罗非昔布在光滑星鲨（Mustelus canis）体内的药代动力学。
8 只在同一栖息地接受人类护理的健康成年雄性光滑星鲨。
所有鲨鱼均在右侧尾侧背外侧肌单次肌肉注射罗非昔布（4.0mg/kg）。在给药后 30 分钟、1 小时、2 小时、4 小时、8 小时和 24 小时，通过手动限制从腹侧尾血管采集血样。通过 HPLC 测定血浆药物浓度，并对数据进行非房室药代动力学分析。
罗非昔布给药后平均 30 分钟达到最大血浆浓度 1.24µg/mL，血浆消除半衰期为 3.79 小时。在本研究采样的时间点，血浆浓度未降至定量下限（0.1µg/mL）。
在光滑星鲨单次肌肉注射（4.0mg/kg）单剂量罗非昔布后，药物迅速吸收，在给药后约 30 分钟达到最大浓度，并至少在 8 小时内维持在被认为对国内物种具有治疗作用的水平之上。
