在实验室微型计算机上使用单纯形法优化非线性函数。

The use of the simplex method for the optimisation of non-linear functions on a laboratory microcomputer.

作者信息

Nicol R, Smith P, Raggatt P R

出版信息

Comput Biol Med. 1986;16(2):145-52. doi: 10.1016/0010-4825(86)90038-7.

Abstract

The use of the microcomputer for the processing of analytical data in the laboratory is currently increasing. However, computational methods which have been used successfully on minicomputers may not be suitable for microcomputer implementation due to the lack of available precision. This paper describes a technique, namely the simplex method, which may be successfully applied to the processing of laboratory data on an 8-bit microcomputer. The method is used to optimise a non-linear function in order to fit a curve to radioimmunoassay (RIA) and immunoradiometricassay (IRMA) data. The microcomputer package described has been tested on laboratory data and is currently in use in a clinical biochemistry laboratory.

摘要

目前，实验室中使用微型计算机处理分析数据的情况正在增加。然而，由于缺乏可用的精度，在小型计算机上成功使用的计算方法可能不适用于微型计算机。本文描述了一种技术，即单纯形法，它可以成功地应用于8位微型计算机处理实验室数据。该方法用于优化非线性函数，以便将曲线拟合到放射免疫分析（RIA）和免疫放射分析（IRMA）数据。所描述的微型计算机软件包已经在实验室数据上进行了测试，目前正在一家临床生物化学实验室中使用。