Shahin Khashayar, Soleimani-Delfan Abbas, He Zihan, Sansonetti Philippe, Collard Jean-Marc
Center for Microbes, Development, and Health (CMDH), Institute Pasteur of Shanghai/Chinese Academy of Sciences, Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai, 200031, China.
Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Hezar Jereeb Street, Isfahan, 81746-73441, Iran.
Gut Pathog. 2023 Aug 4;15(1):39. doi: 10.1186/s13099-023-00561-0.
The human gut bacteriome is believed to have pivotal influences on human health and disease while the particular roles associated with the gut phageome have not been fully characterized yet with few exceptions. It is argued that gut microbiota can have a potential role in autism spectrum disorders (ASD). The public microbiota database of ASD and typically developing (TD) Chinese individuals were analyzed for phage protein-coding units (pPCU) to find any link between the phageome and ASD. The gut phageome of ASD individuals showed a wider diversity and higher abundance compared to TD individuals. The ASD phageome was associated with a significant expansion of Caudoviricetes bacteriophages. Phages infecting Bacteroidaceae and prophages encoded within Faecalibacterium were more frequent in ASD than in TD individuals. The expansion and diversification of ASD phageome can influence the bacterial homeostasis by imposing pressure on the bacterial communities. In conclusion, the differences of phages community in in ASD and TD can be used as potential diagnosis biomarkers of ASD. Further investigations are needed to verify the role of gut phage communities in the pathogenesis of ASD.
人们认为，人类肠道细菌群落对人类健康和疾病具有关键影响，而与肠道噬菌体群落相关的特定作用尚未完全明确，仅有少数例外情况。有人认为肠道微生物群可能在自闭症谱系障碍（ASD）中发挥潜在作用。分析了ASD中国个体和发育正常（TD）中国个体的公共微生物群数据库中的噬菌体蛋白质编码单元（pPCU），以寻找噬菌体群落与ASD之间的任何联系。与TD个体相比，ASD个体的肠道噬菌体群落表现出更广泛的多样性和更高的丰度。ASD噬菌体群落与长尾噬菌体目噬菌体的显著扩增有关。感染拟杆菌科的噬菌体以及在粪杆菌中编码的原噬菌体在ASD个体中比在TD个体中更常见。ASD噬菌体群落的扩增和多样化可通过对细菌群落施加压力来影响细菌稳态。总之，ASD和TD个体中噬菌体群落的差异可作为ASD潜在的诊断生物标志物。需要进一步研究以验证肠道噬菌体群落在ASD发病机制中的作用。
