Hb Owari [alpha 121 (H 4) Val----Met]: a new hemoglobin variant with a neutral-to-neutral amino acid substitution detected by isoelectric focusing.

An abnormal hemoglobin, Hb Owari [alpha 121 (H 4) Val----Met], was discovered in seven Japanese. This variant was isoelectrofocused to the site between the Hb A and Hb F bands and amounted to 12.7-19.0% of the total hemoglobin in the hemolysate. This hemoglobin showed normal functional properties.