Banerjee Juni, Ranjan Ramya P, Alam Md Tanjim, Deshmukh Sanika, Tripathi Prem Prakash, Gandhi Sonu, Banerjee Shuvomoy
Institute of Advanced Research, Koba Institutional Area, Gandhinagar, Gujarat 382426, India.
National Institute of Animal Biotechnology (NIAB), Gachibowli, Hyderabad, Telangana 500032, India.
Pathol Res Pract. 2023 Aug;248:154720. doi: 10.1016/j.prp.2023.154720. Epub 2023 Jul 27.
Neuroendocrine neoplasms (NENs) comprise malignancies involving neuroendocrine cells that often lead to fatal pathological conditions. Despite escalating global incidences, NENs still have poor prognoses. Interestingly, research indicates an intricate association of tumor viruses with NENs. However, there is a dearth of comprehension of the complete scenario of NEN pathophysiology and its precise connections with the tumor viruses. Interestingly, several cutting-edge experiments became helpful for further screening of NET for the presence of polyomavirus, Human papillomavirus (HPV), Kaposi sarcoma-associated herpesvirus (KSHV), Epstein Barr virus (EBV), etc. Current research on the neuroendocrine tumor (NET) pathogenesis provides new information concerning their molecular mechanisms and therapeutic interventions. Of note, scientists observed that metastatic neuroendocrine tumors still have a poor prognosis with a palliative situation. Different oncolytic vector has already demonstrated excellent efficacies in clinical studies. Therefore, oncolytic virotherapy or virus-based immunotherapy could be an emerging and novel therapeutic intervention. In-depth understanding of all such various aspects will aid in managing, developing early detection assays, and establishing targeted therapeutic interventions for NENs concerning tumor viruses. Hence, this review takes a novel approach to discuss the dual role of tumor viruses in association with NENs' pathophysiology as well as its potential therapeutic interventions.
神经内分泌肿瘤（NENs）包括涉及神经内分泌细胞的恶性肿瘤，这些肿瘤常常导致致命的病理状况。尽管全球发病率不断上升，但NENs的预后仍然很差。有趣的是，研究表明肿瘤病毒与NENs之间存在复杂的关联。然而，对于NEN病理生理学的完整情况及其与肿瘤病毒的确切联系，人们仍缺乏了解。有趣的是，一些前沿实验有助于进一步筛查神经内分泌肿瘤（NET）中是否存在多瘤病毒、人乳头瘤病毒（HPV）、卡波西肉瘤相关疱疹病毒（KSHV）、爱泼斯坦-巴尔病毒（EBV）等。目前关于神经内分泌肿瘤（NET）发病机制的研究提供了有关其分子机制和治疗干预的新信息。值得注意的是，科学家观察到转移性神经内分泌肿瘤在姑息治疗情况下的预后仍然很差。不同的溶瘤载体已在临床研究中显示出优异的疗效。因此，溶瘤病毒疗法或基于病毒的免疫疗法可能是一种新兴的新型治疗干预措施。深入了解所有这些不同方面将有助于管理、开发早期检测方法，并为与肿瘤病毒相关的NENs建立靶向治疗干预措施。因此，本综述采用一种新颖的方法来讨论肿瘤病毒在NENs病理生理学中的双重作用及其潜在的治疗干预措施。
