饮食与多囊肾病：营养素、食物、饮食模式及其对实践的意义。

Diet and Polycystic Kidney Disease: Nutrients, Foods, Dietary Patterns, and Implications for Practice.

机构信息

Nutrition and Dietetics, School of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, New South Wales, Australia.

PKD Australia, Sydney, New South Wales, Australia.

出版信息

Semin Nephrol. 2023 Mar;43(2):151405. doi: 10.1016/j.semnephrol.2023.151405. Epub 2023 Aug 4.

DOI:10.1016/j.semnephrol.2023.151405

PMID:37542985

Abstract

Polycystic kidney disease (PKD) is a chronic, progressive hereditary condition characterized by abnormal development and growth of cysts in the kidneys and other organs. There is increasing interest in exploring whether dietary modifications may prevent or slow the disease course in people with PKD. Although vasopressin-receptor agonists have emerged as a novel drug treatment in advancing care for people with PKD, several recent landmark trials and clinical discoveries also have provided new insights into potential dietary-related therapeutic strategies. In this review, we summarize the current evidence pertaining to nutrients, foods, dietary patterns, cyst growth, and progression of PKD. We also describe existing evidence-based dietary care for people with PKD and outline the potential implications for advancing evidence-based dietary interventions. Semin Nephrol 43:x-xx © 2023 Elsevier Inc. All rights reserved.

摘要

多囊肾病 (PKD) 是一种慢性、进行性遗传性疾病，其特征是肾脏和其他器官中的囊肿异常发育和生长。人们越来越感兴趣地探索饮食改变是否可以预防或减缓 PKD 患者的疾病进程。尽管血管加压素受体激动剂作为一种新的药物治疗方法在 PKD 患者的治疗中出现，但最近的几项标志性试验和临床发现也为潜在的与饮食相关的治疗策略提供了新的见解。在这篇综述中，我们总结了与营养素、食物、饮食模式、囊肿生长和 PKD 进展相关的现有证据。我们还描述了现有的针对 PKD 患者的循证饮食护理，并概述了推进循证饮食干预的潜在意义。《 Semin Nephrol》43:x-xx © 2023 Elsevier Inc. 保留所有权利。