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述评:在绵羊模型中,使用具有双相结构(钙化和去矿化)的松质骨间置同种异体移植物增强肩袖修复术不会引起有害炎症或异物反应。

Editorial Commentary: A Biphasic (Calcified and Demineralized), Cancellous, Interpositional Allograft Augmenting Rotator Cuff Repair in an Ovine Model Does Not Show Harmful Inflammation or Foreign Body Reaction.

出版信息

Arthroscopy. 2023 Sep;39(9):1998-1999. doi: 10.1016/j.arthro.2023.04.008.

DOI:10.1016/j.arthro.2023.04.008
PMID:37543384
Abstract

To improve the outcomes of arthroscopic rotator cuff (RC) repair, it is important to achieve tendon-to-bone healing at the repair site. Healed repairs are more likely to restore shoulder strength and lead to higher magnitudes of satisfaction. Patches or grafts that can be either secured to the bursal surface of the RC or interposed between the RC tendon and greater tuberosity at the time of repair have been described as adjuncts to RC repair. A cancellous, biphasic allograft tissue composed of 2 layers (calcified to promote osseointegration and demineralized to support soft-tissue ingrowth) has been shown to be safe in an ovine model, without a harmful inflammatory or foreign body response. Human trials may be a reasonable next step.

摘要

为了提高关节镜下肩袖(RC)修复的效果,重要的是要实现修复部位的腱骨愈合。愈合的修复更有可能恢复肩部力量,并带来更高程度的满意度。在修复时可以固定在 RC 囊面或RC 肌腱和大结节之间的补丁或移植物被描述为 RC 修复的辅助物。一种由 2 层组成的松质、双相同种异体组织(钙化以促进骨整合,脱矿质以支持软组织向内生长)已在绵羊模型中证明是安全的,没有有害的炎症或异物反应。人体试验可能是下一步的合理选择。

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Editorial Commentary: A Biphasic (Calcified and Demineralized), Cancellous, Interpositional Allograft Augmenting Rotator Cuff Repair in an Ovine Model Does Not Show Harmful Inflammation or Foreign Body Reaction.述评:在绵羊模型中,使用具有双相结构(钙化和去矿化)的松质骨间置同种异体移植物增强肩袖修复术不会引起有害炎症或异物反应。
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