肠道微生物群与非酒精性脂肪性肝病的关联：一项两样本孟德尔随机化研究。
Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study.
机构信息
School of Nursing, Jining Medical University, Jining, 272067, China; School of Nursing, Weifang Medical University, Weifang, 261042, China.
Department of Critical Care Medicine, The People's Hospital of Zhaoyuan City, Yantai 265400, China.
出版信息
Dig Liver Dis. 2023 Nov;55(11):1464-1471. doi: 10.1016/j.dld.2023.07.014. Epub 2023 Aug 4.
BACKGROUND
Increasing studies have shown that there is a significant association between gut microbiota and non-alcoholic fatty liver disease.
AIMS
To show the potential association between gut microbiota and non-alcoholic fatty liver disease, we performed a two-sample Mendelian randomization analysis.
METHODS
We analyzed summary statistics from genome-wide association studies of gut microbiota and non-alcoholic fatty liver disease and conducted Mendelian randomization studies to evaluate relationships between these factors.
RESULTS
Of the 211 gut microbiota taxa examined, the inverse variance weighted method identified Lactobacillaceae (OR = 0.83, 95% CI = 0.72 - 0.95, P = 0.007), Christensenellaceae (OR = 0.74, 95% CI = 0.59 - 0.92, P = 0.007), and Intestinibacter (OR = 0.85, 95% CI = 0.73 - 0.99, P = 0.035) were negatively correlated with non-alcoholic fatty liver disease. And Coriobacteriia (OR = 1.22, 95% CI = 1.01 - 1.42, P = 0.038), Actinomycetales (OR = 1.25, 95% CI = 1.02 - 1.53, P = 0.031), Oxalobacteraceae (OR = 1.10, 95% CI = 1.01 - 1.21, P = 0.036), Ruminococcaceae_UCG005 (OR = 1.18, 95% CI = 1.01 - 1.38, P = 0.033) are positively associated with non-alcoholic fatty liver disease.
CONCLUSIONS
Our study found that the abundance of certain strains was associated with the progression of nonalcoholic fatty liver disease.
背景
越来越多的研究表明，肠道微生物群与非酒精性脂肪性肝病之间存在显著关联。
目的
为了展示肠道微生物群与非酒精性脂肪性肝病之间的潜在关联，我们进行了两样本 Mendelian 随机分析。
方法
我们分析了肠道微生物群和非酒精性脂肪性肝病的全基因组关联研究的汇总统计数据，并进行了 Mendelian 随机研究来评估这些因素之间的关系。
结果
在所检查的 211 种肠道微生物群中，逆方差加权法确定了乳杆菌科（OR=0.83，95%CI=0.72-0.95，P=0.007）、克里斯滕森菌科（OR=0.74，95%CI=0.59-0.92，P=0.007）和肠杆菌科（OR=0.85，95%CI=0.73-0.99，P=0.035）与非酒精性脂肪性肝病呈负相关。而 Coriobacteriia（OR=1.22，95%CI=1.01-1.42，P=0.038）、放线菌目（OR=1.25，95%CI=1.02-1.53，P=0.031）、草酸杆菌科（OR=1.10，95%CI=1.01-1.21，P=0.036）和 Ruminococcaceae_UCG005（OR=1.18，95%CI=1.01-1.38，P=0.033）与非酒精性脂肪性肝病呈正相关。
结论
本研究发现某些菌株的丰度与非酒精性脂肪性肝病的进展有关。
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