分娩风险表型与早产儿早发性败血症的关联。
Association of delivery risk phenotype with early-onset sepsis in preterm infants.
机构信息
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.
出版信息
J Perinatol. 2023 Sep;43(9):1166-1172. doi: 10.1038/s41372-023-01743-z. Epub 2023 Aug 5.
OBJECTIVE
To determine delivery risk phenotype-specific incidence of early-onset sepsis (EOS) among preterm infants.
STUDY DESIGN
Retrospective cohort study of infants born <35 weeks' gestation at four perinatal centers during 2017-2021. Infants were classified into one of six delivery risk phenotypes incorporating delivery mode, presence of labor, and duration of rupture of membranes (ROM). The primary outcome was EOS incidence within the overall cohort and each risk phenotype.
RESULTS
Among 2937 preterm infants, 21 had EOS (0.7%, or 7.1 cases/1000 preterm infants). The majority of EOS cases (13/21, 62%) occurred in the setting of prolonged ROM ≥ 18 h, with a phenotype incidence of 23.8 cases/1000 preterm infants. There were no EOS cases among infants born by cesarean section without ROM (with or without labor), nor via cesarean section with ROM < 18 h without labor.
CONCLUSION
Delivery risk phenotyping may inform EOS risk stratification in preterm infants.
目的
确定早产婴儿中特定于分娩风险表型的早发性败血症（EOS）发生风险。
研究设计
对 2017 年至 2021 年期间在四个围产期中心出生的 <35 周妊娠的婴儿进行回顾性队列研究。婴儿被分为六种分娩风险表型之一，其中包括分娩方式、存在临产和破膜（ROM）持续时间。主要结局是在整个队列和每个风险表型中发生 EOS 的发生率。
结果
在 2937 名早产儿中，有 21 名患有 EOS（0.7%，即 1000 名早产儿中有 7.1 例）。大多数 EOS 病例（13/21，62%）发生在 ROM≥18 小时的情况下，其表型发生率为每 1000 名早产儿中有 23.8 例。在没有 ROM（无论有无临产）或无临产且 ROM<18 小时的情况下通过剖宫产分娩的婴儿中，没有 EOS 病例。
结论
分娩风险表型分析可能为早产婴儿的 EOS 风险分层提供信息。
Zotero 插件