From the Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases.
Department of Traditional Chinese Medicine.
Clin Nucl Med. 2023 Sep 1;48(9):781-784. doi: 10.1097/RLU.0000000000004724. Epub 2023 May 26.
68Ga-DOTA-FAPI-04 PET/CT was performed on a cohort of 21 patients with known SAPHO syndrome. All patients underwent 68Ga-DOTA-FAPI-04 and 18F-FDG PET/CT on 2 consecutive days. The positive rates of the PET/CT scans at the sites of the osteoarticular symptom, the uptake values, and agreement with clinical osteoarticular symptom were compared.
A total of 38 sites of involvement were detected. 18F-FDG PET/CT revealed 28 lesions. In contrast, 68Ga-DOTA-FAPI-04 PET/CT detected not only all lesions shown on 18F-FDG PET/CT but additional 10 lesions. 68Ga-DOTA-FAPI-04 scan also demonstrated significantly higher uptake and target-to-background ratio than 18F-FDG studies in the skeletal involvements. The agreement between 68Ga-DOTA-FAPI-04-positive lesions and current osteoarticular lesions was substantial (κ = 0.79, P < 0.001), whereas 18F-FDG had low to moderate agreement with clinical symptoms (κ = 0.52, P < 0.001).
68Ga-DOTA-FAPI-04 has potential as a promising imaging agent for the evaluation of SAPHO syndrome.
对 21 名已知 SAPHO 综合征的患者进行了 68Ga-DOTA-FAPI-04 PET/CT 检查。所有患者在连续两天内接受了 68Ga-DOTA-FAPI-04 和 18F-FDG PET/CT 检查。比较了骨骼关节症状部位的 PET/CT 扫描的阳性率、摄取值以及与临床骨骼关节症状的一致性。
共发现 38 个受累部位。18F-FDG PET/CT 显示 28 个病变。相比之下，68Ga-DOTA-FAPI-04 PET/CT 不仅检测到了 18F-FDG PET/CT 显示的所有病变，还额外检测到了 10 个病变。68Ga-DOTA-FAPI-04 扫描在骨骼受累部位的摄取量和靶与背景比也明显高于 18F-FDG 研究。68Ga-DOTA-FAPI-04 阳性病变与当前骨骼关节病变之间的一致性较高（κ=0.79，P<0.001），而 18F-FDG 与临床症状的一致性较低（κ=0.52，P<0.001）。
68Ga-DOTA-FAPI-04 作为评估 SAPHO 综合征的有前途的成像剂具有潜力。
