Hospital of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, PR China.
Department of Gastroenterology, The Fifth Affiliated Hospital of Southern Medical University, Guangdong, PR China.
Medicine (Baltimore). 2023 Aug 4;102(31):e34515. doi: 10.1097/MD.0000000000034515.
The purpose of this study was to evaluate the association between the waist-to-height ratio (WHtR) and the aggravation of acute pancreatitis (AP). This prospective study included AP patients treated from May 2019 to December 2019 in the Department of Gastroenterology, the First Affiliated Hospital of Nanchang University. Receiver operating characteristic curves were constructed to determine the optimal threshold values for predicting the aggravation of AP. Risk factor analysis was performed via logistic regression analysis. Of 258 patients included in this study, 77 (29.84%) were diagnosed with mild acute pancreatitis, 120 (46.51%) with moderately severe acute pancreatitis, and 61 (23.64%) with severe acute pancreatitis (SAP). WHtR, waist circumference, weight, and body mass index were all associated with AP severity, and the highest area under the receiver operating characteristic value was observed for WHtR. The optimal threshold WHtR value for predicting SAP was 0.567. Multivariate logistic regression analysis identified WHtR ≥ 0.567 as independent risk factor for SAP. Moreover, the hospital stay was longer and intensive care unit admission rate was higher among AP patients with a WHtR ≥ 0.567. The WHtR was found to be closely related to the severity of AP and an independent risk factor for the aggravation of AP. This simple parameter can aid the early prediction of AP progression, thereby facilitating early intervention and improving patient outcomes.
本研究旨在评估腰高比（WHtR）与急性胰腺炎（AP）加重之间的关联。这项前瞻性研究纳入了 2019 年 5 月至 2019 年 12 月南昌大学第一附属医院消化内科收治的 AP 患者。通过构建受试者工作特征曲线确定预测 AP 加重的最佳 WHtR 截断值。采用 logistic 回归分析进行风险因素分析。本研究共纳入 258 例患者，其中轻度急性胰腺炎 77 例（29.84%），中度重症急性胰腺炎 120 例（46.51%），重症急性胰腺炎（SAP）61 例（23.64%）。WHtR、腰围、体重和体重指数均与 AP 严重程度相关，WHtR 的受试者工作特征曲线下面积最高。预测 SAP 的最佳 WHtR 截断值为 0.567。多因素 logistic 回归分析表明 WHtR≥0.567 是 SAP 的独立危险因素。此外，WHtR≥0.567 的 AP 患者住院时间更长，入住重症监护病房的比例更高。WHtR 与 AP 的严重程度密切相关，是 AP 加重的独立危险因素。该简单参数可有助于早期预测 AP 的进展，从而便于早期干预，改善患者结局。
