未使用的处方：在 COVID-19 大流行前后调查马萨诸塞州患者使用丁丙诺啡治疗的体验。
Unfilled prescriptions: Surveying patients' experiences with buprenorphine treatment in Massachusetts before and during the COVID-19 pandemic.
机构信息
Department of Psychiatry, Cambridge Health Alliance, Cambridge, Massachusetts, USA.
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Am J Addict. 2023 Nov;32(6):615-618. doi: 10.1111/ajad.13460. Epub 2023 Aug 6.
BACKGROUND AND OBJECTIVES
We explored potential challenges to accessing office-based opioid treatment (OBOT) with buprenorphine during the COVID-19 pandemic.
METHODS
Using Facebook advertisements, we recruited a sample of N = 72 participants and conducted four repeated-measures analysis of variance comparing ratings of participants' abilities to access aspects of OBOT treatment.
RESULTS
Participants reported increased difficulty filling buprenorphine prescriptions during the pandemic than before, p = .011, partial η = 0.092, and this was correlated with past month opioid use, r = .236, p = .042.
DISCUSSION, CONCLUSIONS, AND SCIENTIFIC SIGNIFICANCE: This is the first investigation to report unfilled prescriptions during the pandemic and an association with opioid use. Unfilled prescriptions may contribute to relapse and partially explain increased overdose deaths during COVID-19.
背景与目的
我们探讨了在 COVID-19 大流行期间，接受丁丙诺啡门诊阿片类药物治疗（OBOT）可能面临的挑战。
方法
我们使用 Facebook 广告招募了 72 名参与者，并进行了四次重复测量方差分析，比较参与者在评估自身接受 OBOT 治疗各方面能力时的评分。
结果
与大流行前相比，参与者报告在大流行期间更难以开具丁丙诺啡处方，p=.011，部分η²=0.092，这与过去一个月的阿片类药物使用呈正相关，r=0.236，p=0.042。
讨论、结论和科学意义：这是首次报告大流行期间存在未开具处方的情况，并与阿片类药物使用有关。未开具处方可能导致复发，并在一定程度上解释了 COVID-19 期间过量死亡人数增加的原因。
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