University of Health Sciences, Zeynep Kamil Maternity and Children's Training and Research Hospital -Istanbul, Turkey.
Arch Iran Med. 2022 Aug 1;25(8):547-551. doi: 10.34172/aim.2022.87.
We aimed to assess the factors associated with the transition time to full enteral feeding (FEF) in newborns with hypoxic ischemic encephalopathy (HIE) undergoing therapeutic hypothermia.
We obtained data retrospectively from medical records of the neonates diagnosed with HIE and treated by therapeutic hypothermia to evaluate the factors associated with transition time to FEF.
Sixty-one neonates were included in the study. The median gestational age (GA) and birth weight were 39 (37-40) weeks and 3245 (2715-3575) grams, respectively. APGAR scores at the first and fifth minutes were 3 (1-5) and 6 (4-7), respectively. Fifty-seven (93.4%) of the newborns were diagnosed as having moderate HIE, and 4 (6.6%) of them had severe HIE. Transition time to FEF was found to be negatively correlated with gestational week (, : -0.280, 0.029) and birth weight (, : -0.315, 0.013); and positively correlated with lactate (, : 0.295, 0.044), BUN (, : 0.285, 0.026) and creatinine levels (: 0.345, 0.007); duration of invasive (, : 0.565, 0.0001) and non-invasive mechanical ventilation (, : 0.261, 0.042), use of antibiotics (, : 0.556, 0.0001) and inotropic agents (, : 0.524, 0.0001) and hospitalization (, : 0.654, 0.0001).
Clinicians should be more careful while starting to feed babies undergoing therapeutic hypothermia with higher lactate levels and impaired renal functions, and should be encouraged to feed clinically stable neonates with HIE as soon as possible, as the transition time to FEF could be related with better clinical outcomes.
我们旨在评估接受治疗性低温治疗的患有缺氧缺血性脑病（HIE）的新生儿过渡到全肠内喂养（FEF）的时间的相关因素。
我们从接受治疗性低温治疗的 HIE 新生儿的病历中回顾性地获得数据，以评估与过渡到 FEF 的时间相关的因素。
研究纳入了 61 例新生儿。中位胎龄（GA）和出生体重分别为 39（37-40）周和 3245（2715-3575）克。第 1 分钟和第 5 分钟的 APGAR 评分分别为 3（1-5）和 6（4-7）。57（93.4%）例新生儿被诊断为中度 HIE，4（6.6%）例新生儿为重度 HIE。FEF 的过渡时间与胎龄（，：-0.280，0.029）和出生体重（，：-0.315，0.013）呈负相关；与乳酸（，：0.295，0.044）、BUN（，：0.285，0.026）和肌酐水平（，：0.345，0.007）呈正相关；与有创（，：0.565，0.0001）和无创机械通气（，：0.261，0.042）、抗生素（，：0.556，0.0001）和正性肌力药物（，：0.524，0.0001）的使用和住院时间（，：0.654，0.0001）呈正相关。
临床医生在开始给接受治疗性低温治疗的婴儿喂养时，应更加注意高乳酸水平和肾功能受损的婴儿，并应鼓励尽快给患有 HIE 的临床稳定的新生儿喂养，因为过渡到 FEF 的时间可能与更好的临床结果有关。
