Neuronal Circuits and Behaviour Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain; Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain.
Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain.
Cell Rep. 2023 Aug 29;42(8):112950. doi: 10.1016/j.celrep.2023.112950. Epub 2023 Aug 5.
Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs in a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction to the processing of sensory inputs and consequent behavior remains unclear. We investigate the role of astrocytes in sensory information processing at circuit and behavioral levels by monitoring and manipulating astrocytic activity in vivo. We show that astrocytes control the dynamic range of the cortical network activity, optimizing its responsiveness to incoming sensory inputs. The astrocytic modulation of sensory processing contributes to setting the detection threshold for tactile and thermal behavior responses. The mechanism of such astrocytic control is mediated through modulation of inhibitory transmission to adjust the gain and sensitivity of responding networks. These results uncover a role for astrocytes in maintaining the cortical network activity in an optimal range to control behavior associated with specific sensory modalities.
皮质神经元-星形胶质细胞通讯对外周感觉刺激的反应具有拓扑、频率和强度依赖性。然而，这种功能相互作用对感觉输入的处理和随后的行为的贡献尚不清楚。我们通过在体内监测和操纵星形胶质细胞活性来研究星形胶质细胞在回路和行为水平上对感觉信息处理的作用。我们表明，星形胶质细胞控制皮质网络活动的动态范围，使其对传入感觉输入的反应更优化。星形胶质细胞对感觉处理的调节有助于为触觉和热行为反应设定检测阈值。这种星形胶质细胞控制的机制是通过调节抑制性传递来调节响应网络的增益和敏感性。这些结果揭示了星形胶质细胞在维持皮质网络活动处于最佳范围以控制与特定感觉模式相关的行为方面的作用。
