Elling D, Bader K
Arch Geschwulstforsch. 1986;56(1):23-33.
A continuous monitoring by chromatographic determination of 10 free serum amino acids was carried out in 21 breast cancer patients. The results show, that the pretherapeutic levels of asparagine, glutamine, alanine, isoleucine, leucine, tyrosine and phenylalanine are significantly elevated if the disease progressed within the next two years. Asparagine, glutamine, glycine, alanine, tyrosine and phenylalanine are significantly elevated if no progression could be observed. In patients without progression the level of free serum amino acid went back to normal during one year. The determination of free serum amino acid is qualified for monitoring the treatment results in breast cancer patients.
对21例乳腺癌患者进行了10种游离血清氨基酸的色谱测定连续监测。结果表明,如果疾病在接下来的两年内进展,天冬酰胺、谷氨酰胺、丙氨酸、异亮氨酸、亮氨酸、酪氨酸和苯丙氨酸的治疗前水平会显著升高。如果未观察到进展,天冬酰胺、谷氨酰胺、甘氨酸、丙氨酸、酪氨酸和苯丙氨酸会显著升高。在无进展的患者中,游离血清氨基酸水平在一年内恢复正常。游离血清氨基酸的测定有资格用于监测乳腺癌患者的治疗效果。