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塑造树突景观:肌动蛋白、微管和分支的艺术。

Sculpting the dendritic landscape: Actin, microtubules, and the art of arborization.

机构信息

Wellcome Centre for Cell Biology & Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK.

Wellcome Centre for Cell Biology & Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, EH9 3BF, UK.

出版信息

Curr Opin Cell Biol. 2023 Oct;84:102214. doi: 10.1016/j.ceb.2023.102214. Epub 2023 Aug 4.

Abstract

Dendrites are intricately designed neuronal compartments that play a vital role in the gathering and processing of sensory or synaptic inputs. Their diverse and elaborate structures are distinct features of neuronal organization and function. Central to the generation of these dendritic arbors is the neuronal cytoskeleton. In this review, we delve into the current progress toward our understanding of how dendrite arbors are generated and maintained, focusing on the role of the actin and microtubule cytoskeleton.

摘要

树突是神经元中错综复杂的结构,在接收和处理感觉或突触输入方面起着至关重要的作用。其多样而精细的结构是神经元组织和功能的显著特征。树突分支的产生主要依赖于神经元细胞骨架。在这篇综述中,我们深入探讨了目前对树突分支产生和维持机制的理解进展,重点关注肌动蛋白和微管细胞骨架的作用。

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