Schifferli J A, Despont J P, Cruchaud A, Carpentier N, Jeannet M, Schmidt M
Arch Pathol Lab Med. 1986 May;110(5):425-9.
Circulating autoantibodies directed at creatine kinase (CK) BB isozyme are detected in plasma in the form of an immune complex (immunoglobulin CK BB) termed macro-CK type 1. Fourteen patients presented a falsely elevated CK MB isozyme fraction as measured by the immunoinhibition method; they were found to have IgG-CK BB complexes, which was considered to be indirect evidence of circulating anti-CK BB autoantibodies. No evident clinical association between the detection of this autoantibody in complexed form and autoimmune disease could be established, there was no significantly increased incidence of other autoantibodies, and there was no specific alteration in immunoglobulin and complement levels; however, the HLA haplotype A1,B8,DR3, which is known to be associated with autoimmunity, was present in five patients.
血浆中可检测到以免疫复合物（免疫球蛋白CK BB）形式存在的针对肌酸激酶（CK）BB同工酶的循环自身抗体，称为1型巨CK。通过免疫抑制法检测，14例患者的CK MB同工酶分数假性升高；发现他们存在IgG-CK BB复合物，这被认为是循环抗CK BB自身抗体的间接证据。无法确定这种复合形式自身抗体的检测与自身免疫性疾病之间存在明显的临床关联，其他自身抗体的发生率没有显著增加，免疫球蛋白和补体水平也没有特异性改变；然而，已知与自身免疫相关的HLA单倍型A1、B8、DR3在5例患者中出现。
