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能量代谢:心血管损伤的关键靶点。

Energy metabolism: A critical target of cardiovascular injury.

机构信息

Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and the Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and Universities, Gansu University of Chinese Medicine, Lanzhou, China.

Gansu Institute of Cardiovascular Diseases, LanZhou, China.

出版信息

Biomed Pharmacother. 2023 Sep;165:115271. doi: 10.1016/j.biopha.2023.115271. Epub 2023 Aug 4.

Abstract

Cardiovascular diseases are the main killers threatening human health. Many studies have shown that abnormal energy metabolism plays a key role in the occurrence and development of acute and chronic cardiovascular diseases. Regulating cardiac energy metabolism is a frontier topic in the treatment of cardiovascular diseases. However, we are not very clear about the choice of different substrates, the specific mechanism of energy metabolism participating in the course of cardiovascular disease, and how to develop appropriate drugs to regulate energy metabolism to treat cardiovascular disease. Therefore, this paper reviews how energy metabolism participates in cardiovascular pathophysiological processes and potential drugs aimed at interfering energy metabolism.It is expected to provide good suggestions for promoting the clinical prevention and treatment of cardiovascular diseases from the perspective of energy metabolism.

摘要

心血管疾病是威胁人类健康的主要杀手。大量研究表明,异常的能量代谢在急、慢性心血管疾病的发生发展中起关键作用。调节心脏能量代谢是治疗心血管疾病的一个前沿课题。然而,我们对于不同底物的选择、能量代谢参与心血管疾病病程的具体机制以及如何开发合适的调节能量代谢的药物来治疗心血管疾病尚不是非常清楚。因此,本文综述了能量代谢如何参与心血管病理生理过程以及潜在的以干预能量代谢为靶点的药物,以期从能量代谢角度为促进心血管疾病的临床防治提供良好建议。

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