School of Sciences, Xichang University, Xichang, Sichuan 615000, PR China.
School of Sciences, Xichang University, Xichang, Sichuan 615000, PR China.
Fitoterapia. 2023 Oct;170:105643. doi: 10.1016/j.fitote.2023.105643. Epub 2023 Aug 5.
The chemical analysis on the aerial sections of Eupatorium adenophorum Spreng. resulted in the identification of four unprecedented 5/5 fused bicyclosesquiterpenoids, eupatorid A (1), and its analogues named eupatorester A-C (2-4) using various chromatographic techniques. Their structures were unambiguously confirmed by detailed spectroscopic investigations (including 1D, 2D-NMR and HRMS), and single crystal X-ray diffraction. The anti-inflammatory activities, in vitro tumor growth inhibitory activities and antibacterial activities of these compounds were evaluated.
对紫茎泽兰地上部分的化学分析导致了四个前所未有的 5/5 融合双环倍半萜的鉴定，即泽兰内酯 A（1）及其类似物命名为泽兰内酯 A-C（2-4），使用了各种色谱技术。通过详细的光谱研究（包括 1D、2D-NMR 和 HRMS）和单晶 X 射线衍射，明确了它们的结构。评估了这些化合物的抗炎活性、体外肿瘤生长抑制活性和抗菌活性。
